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- W2184029752 endingPage "96" @default.
- W2184029752 startingPage "383" @default.
- W2184029752 abstract "The successful clinical translation of novel therapeutic strategies to attenuate lethal myocardial ischemia-reperfusion injury and limit infarct size has been identified as a major unmet need, and is of particular importance in patients with type-2 diabetes. There is a wealth of preclinical evidence that ischemic conditioning (encompassing the three paradigms of preconditioning, postconditioning and remote conditioning) is profoundly cardioprotective and, via up-regulation of endogenous signaling cascades, renders the heart resistant to infarction. However, current phase II trials aimed at exploiting ischemic conditioning for the clinical treatment of myocardial ischemia-reperfusion injury have yielded mixed results, possibly reflecting the emerging concern that the efficacy of conditioning-induced cardioprotection may be compromised in the diabetic heart. Our goal in this review is to provide a summary of our present understanding of the effect of type-2 diabetes on the infarct-sparing effect of ischemic conditioning, and the challenges of limiting ischemia-reperfusion injury in the diabetic heart." @default.
- W2184029752 created "2016-06-24" @default.
- W2184029752 creator A5058895155 @default.
- W2184029752 creator A5071509288 @default.
- W2184029752 date "2014-10-01" @default.
- W2184029752 modified "2023-10-01" @default.
- W2184029752 title "Ischemic conditioning: the challenge of protecting the diabetic heart." @default.
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