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• W2184038425 abstract "Background: This was a pilot study that was conducted to: 1) determine feasibility ofrecruitment, adherence, and follow-up of calorie-restricted low-fat or low-carbohydrate diet plus exercise intervention among overweight and obese premenopausal women; 2) determine if these interventions promoted weight loss; and 3) investigate whether the interventions altered breast cancer biomarkers. Methods: 79 overweight and obese premenopausal women were enrolled in a 52-weekrandomized intervention trial of calorie-restricted low-fat versus calorie-restricted low-carbohydrate diet along with physical activity. Changes in body mass index (BMI) and breast cancer biomarkers such as insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were measured at baseline, 12, 34, and 52 weeks. Results: Among the 550 women screened, 81 were eligible and 79 agreed to participate. Boththe calorie-restricted low-fat and low-carbohydrate diets plus exercise resulted in significant weight loss (average of 3.2 kg across arms, p<0.01). There were no significant changes in IGF-1 or IGFBP-3 in either group; however, IGF-1 had a significant positive relationship with weight loss (p=0.03), with a similar trend observed in each group (p=0.14). Insulin levels decreased an average of 23% between baseline and 52 weeks (p=0.052), with the same trend observed in each group (p=0.88). Conclusions: The feasibility of adherence to both calorie-restricted diets plus exercise over a52-week intervention was low; however, both resulted in weight loss. Weight loss may lead to an increase in IGF-1 and a decrease in insulin. Although this was a relatively small pilot study, a larger study is needed to follow-up on these results." @default.
• W2184038425 created "2016-06-24" @default.
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• W2184038425 date "2014-01-01" @default.
• W2184038425 modified "2023-09-27" @default.
• W2184038425 title "Weight Loss and Breast Cancer Biomarkers in a Randomized Dietary Trial Among Overweight/Obese Premenopausal Women" @default.
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