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• W2184038495 abstract "The main aim of the present study was to evaluate the pharmacokinetics (Pk) of meloxicam, a non-steroidal anti-Inflammatory drug (NSAID), in healthy horses. Eight healthy horses, investigated, were administered meloxicam 0.6 mg.kg -1 body weight. as intravenous bolus, into the jugular vein. Blood samples (5mL) were collected before medication and then 0.12,0.25,0.5,1.0,1.5, 0,3.0,4.0,6.0, 7.0,8.0,9.0, 12.0,24.0, 36.0,48.0, 60,72 and 96 hours post medication. The plasma concentrations of meloxicam were determined in triplicate by the HPLC method developed at UVAS, Lahore and Lahore College For Women University (LCWU), Lahore, Pakistan. The plasma concentration versus time profile was prepared. The mean + SEM values of pharmacokinetic parameters viz area under curve (AUC), steady state volume of distribution (VDss), half-life(t1/2), mean residence time (MRT) and clearance (Cl), determined in horses were 25.43±1.07 μg h mL − 1 , 0.267±0.014 L kg -1 , 8.17±0.03 h, 11.4±0.08 h and 0.023±0.005 L h − 1 kg − 1 respectively. The pharmacokinetic parameters were put in different PK-equations for calculations of dose. On the basis of these findings, we recommend a single IV dose of 0.6 mg.kg -1 Body weight of meloxicam in horses." @default.
• W2184038495 created "2016-06-24" @default.
• W2184038495 creator A5085551031 @default.
• W2184038495 date "2010-01-01" @default.
• W2184038495 modified "2023-09-27" @default.
• W2184038495 title "PHARMACOKINETICS OF ECOFRIENDLY MELOXICAM IN HEALTHY HORSES" @default.
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