Matches in SemOpenAlex for { <https://semopenalex.org/work/W2184080342> ?p ?o ?g. }
- W2184080342 abstract "Methylmercury (MeHg) is a highly toxic environmental pollutant that causes severe neurological disorders. Considering the neuroprotective property of Bacopa monniera, this study was aimed to evaluate protective effect of Bacopa monniera extract (BME) against MeHg induced mitochondrial dysfunction. Rats were exposed to MeHg by gavage (5mg/kg, b.w) and BME was administered (40 mg/kg, orally) 1 hour before of MeHg for 21 days. After treatment period, MeHg exposure significantly increased the immobility time and decreased learning memory. MeHg exposure resulted in DNA fragmentation and Cytochrome c release in cerebellum of rat. BME pre-treatment reverted all the above changes to near normal. Activities of neurotransmitter enzymes MonoamineOxidase (MAO), Acetyl cholinesterase (AChE), Choline acetyltransferase (ChAT) and Electron Transport Chain (ETC) enzymes were found to be decreased after MeHg exposure. Pre-treatment with BME significantly increased the enzyme activities in cerebellum. The results highlighted that Bacopa monniera can alleviate the MeHg induced mitochondrial dysfunction in rat cerebellum." @default.
- W2184080342 created "2016-06-24" @default.
- W2184080342 creator A5004485595 @default.
- W2184080342 creator A5064135859 @default.
- W2184080342 date "2014-01-01" @default.
- W2184080342 modified "2023-09-28" @default.
- W2184080342 title "CHRONIC ADMINISTRATION OF METHYLMERCURY ALTERS COGNITIVE AND MITOCHONDRIAL DYSFUNCTION IN RAT CEREBELLUM – A NOVEL APPROACH TO THERAPY FOR MINAMATA DISEASE BY A MEDHYA RASAYANA DRUG BACOPA MONNIERA" @default.
- W2184080342 cites W133404501 @default.
- W2184080342 cites W1602782999 @default.
- W2184080342 cites W1622099522 @default.
- W2184080342 cites W169404675 @default.
- W2184080342 cites W1967061503 @default.
- W2184080342 cites W1971048984 @default.
- W2184080342 cites W1987126302 @default.
- W2184080342 cites W1991932520 @default.
- W2184080342 cites W1992975043 @default.
- W2184080342 cites W1998047143 @default.
- W2184080342 cites W2002434781 @default.
- W2184080342 cites W2011630444 @default.
- W2184080342 cites W2012258835 @default.
- W2184080342 cites W2015317486 @default.
- W2184080342 cites W2026036597 @default.
- W2184080342 cites W2033984917 @default.
- W2184080342 cites W2037900261 @default.
- W2184080342 cites W2042245650 @default.
- W2184080342 cites W2047416036 @default.
- W2184080342 cites W2055057571 @default.
- W2184080342 cites W2068122949 @default.
- W2184080342 cites W2072219714 @default.
- W2184080342 cites W2074649103 @default.
- W2184080342 cites W2082851670 @default.
- W2184080342 cites W2088465844 @default.
- W2184080342 cites W2089299823 @default.
- W2184080342 cites W2099484254 @default.
- W2184080342 cites W2111604034 @default.
- W2184080342 cites W2113806391 @default.
- W2184080342 cites W2120809284 @default.
- W2184080342 cites W2121334093 @default.
- W2184080342 cites W2127031191 @default.
- W2184080342 cites W2132826785 @default.
- W2184080342 cites W2138414665 @default.
- W2184080342 cites W2155341165 @default.
- W2184080342 cites W2163810480 @default.
- W2184080342 cites W2164760065 @default.
- W2184080342 cites W2169162863 @default.
- W2184080342 cites W2171039595 @default.
- W2184080342 cites W2280173925 @default.
- W2184080342 cites W2341552644 @default.
- W2184080342 cites W2472684632 @default.
- W2184080342 cites W49161754 @default.
- W2184080342 cites W2121423620 @default.
- W2184080342 cites W2187971996 @default.
- W2184080342 hasPublicationYear "2014" @default.
- W2184080342 type Work @default.
- W2184080342 sameAs 2184080342 @default.
- W2184080342 citedByCount "0" @default.
- W2184080342 crossrefType "journal-article" @default.
- W2184080342 hasAuthorship W2184080342A5004485595 @default.
- W2184080342 hasAuthorship W2184080342A5064135859 @default.
- W2184080342 hasConcept C126322002 @default.
- W2184080342 hasConcept C185592680 @default.
- W2184080342 hasConcept C198399640 @default.
- W2184080342 hasConcept C25498285 @default.
- W2184080342 hasConcept C2775910092 @default.
- W2184080342 hasConcept C2779652256 @default.
- W2184080342 hasConcept C71924100 @default.
- W2184080342 hasConcept C98274493 @default.
- W2184080342 hasConceptScore W2184080342C126322002 @default.
- W2184080342 hasConceptScore W2184080342C185592680 @default.
- W2184080342 hasConceptScore W2184080342C198399640 @default.
- W2184080342 hasConceptScore W2184080342C25498285 @default.
- W2184080342 hasConceptScore W2184080342C2775910092 @default.
- W2184080342 hasConceptScore W2184080342C2779652256 @default.
- W2184080342 hasConceptScore W2184080342C71924100 @default.
- W2184080342 hasConceptScore W2184080342C98274493 @default.
- W2184080342 hasLocation W21840803421 @default.
- W2184080342 hasOpenAccess W2184080342 @default.
- W2184080342 hasPrimaryLocation W21840803421 @default.
- W2184080342 hasRelatedWork W1970306448 @default.
- W2184080342 hasRelatedWork W1975457753 @default.
- W2184080342 hasRelatedWork W1979401268 @default.
- W2184080342 hasRelatedWork W1979655796 @default.
- W2184080342 hasRelatedWork W1980447245 @default.
- W2184080342 hasRelatedWork W2002434781 @default.
- W2184080342 hasRelatedWork W2023545466 @default.
- W2184080342 hasRelatedWork W2040088065 @default.
- W2184080342 hasRelatedWork W2064309736 @default.
- W2184080342 hasRelatedWork W2076649634 @default.
- W2184080342 hasRelatedWork W2082128802 @default.
- W2184080342 hasRelatedWork W2100829810 @default.
- W2184080342 hasRelatedWork W2152881560 @default.
- W2184080342 hasRelatedWork W2180136824 @default.
- W2184080342 hasRelatedWork W2327013945 @default.
- W2184080342 hasRelatedWork W2383736925 @default.
- W2184080342 hasRelatedWork W2472684632 @default.
- W2184080342 hasRelatedWork W2751321840 @default.
- W2184080342 hasRelatedWork W4265979 @default.
- W2184080342 hasRelatedWork W1627757902 @default.
- W2184080342 isParatext "false" @default.
- W2184080342 isRetracted "false" @default.