FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2184126015> ?p ?o ?g. }

• W2184126015 endingPage "54" @default.
• W2184126015 startingPage "747" @default.
• W2184126015 abstract "To discuss the role of membrane androgen receptors and to investigate the potential role of testosterone-albumin conjugate in the prostate cancer (PCa) treatment.We identified studies published from 1990 onwards by searching the MEDLINE database of the National Library of Medicine. Initial search terms were androgen receptors, cytoplasmic androgen receptor, and membrane androgen receptor combined with testosterone, testosterone-albumin conjugate, and prostate cancer treatment.The androgen receptor plays a critical role in both development and progression of PCa. The latter is associated with changes in the androgen receptor axis and more precisely, with its conversion from a paracrine dependent signaling pathway for proliferation and survival of prostatic cells to an independent autocrine process. This malignant conversion is due to functional changes in which the androgen receptor activates not only normal genomic, but also novel non-genomic signaling pathways, which are not present in normal prostatic epithelial cells. Thus, treatments for neoadjuvant, adjuvant, and recurrent disease, all center on the regulation and manipulation of the androgen pathway. Recent discoveries however offer strong evidence of a direct apoptotic action induced by activation of the membrane androgen receptor by testosterone-albumin conjugates.Investigation of the molecular pathways of apoptosis through activation of the membrane androgen receptors in the androgen-independent PCa cell is important on the one hand because future manipulation of this mechanism can help with understanding and interpreting unknown to date characteristics of PCa and on the other hand, can contribute to the establishment of activators of membrane androgen receptors. In addition, study of the testosterone-albumin complex can constitute the basis for future treatments for PCa." @default.
• W2184126015 created "2016-06-24" @default.
• W2184126015 creator A5046174197 @default.
• W2184126015 creator A5074483507 @default.
• W2184126015 date "2013-01-01" @default.
• W2184126015 modified "2023-09-27" @default.
• W2184126015 title "Could testosterone have a therapeutic role in prostate cancer?" @default.
• W2184126015 cites W122252942 @default.
• W2184126015 cites W1422392694 @default.
• W2184126015 cites W1501542409 @default.
• W2184126015 cites W1533310838 @default.
• W2184126015 cites W1553342043 @default.
• W2184126015 cites W1558812914 @default.
• W2184126015 cites W1576763630 @default.
• W2184126015 cites W1595712080 @default.
• W2184126015 cites W1675716 @default.
• W2184126015 cites W1907894188 @default.
• W2184126015 cites W1963576492 @default.
• W2184126015 cites W1966822967 @default.
• W2184126015 cites W1974968903 @default.
• W2184126015 cites W1981690551 @default.
• W2184126015 cites W1987888289 @default.
• W2184126015 cites W1998232305 @default.
• W2184126015 cites W2008498145 @default.
• W2184126015 cites W2022462444 @default.
• W2184126015 cites W2035179289 @default.
• W2184126015 cites W2035716637 @default.
• W2184126015 cites W2036446081 @default.
• W2184126015 cites W2039576757 @default.
• W2184126015 cites W2050324116 @default.
• W2184126015 cites W2051956944 @default.
• W2184126015 cites W205692611 @default.
• W2184126015 cites W2058523955 @default.
• W2184126015 cites W2058818042 @default.
• W2184126015 cites W2059389182 @default.
• W2184126015 cites W2059939225 @default.
• W2184126015 cites W2064509352 @default.
• W2184126015 cites W2071732894 @default.
• W2184126015 cites W2073096708 @default.
• W2184126015 cites W2078280901 @default.
• W2184126015 cites W2093505601 @default.
• W2184126015 cites W2096791952 @default.
• W2184126015 cites W2104370607 @default.
• W2184126015 cites W2108014187 @default.
• W2184126015 cites W2113374009 @default.
• W2184126015 cites W2113893197 @default.
• W2184126015 cites W2116990579 @default.
• W2184126015 cites W2118055719 @default.
• W2184126015 cites W2125139539 @default.
• W2184126015 cites W2132424867 @default.
• W2184126015 cites W2136294116 @default.
• W2184126015 cites W2137889099 @default.
• W2184126015 cites W2141652903 @default.
• W2184126015 cites W2147464878 @default.
• W2184126015 cites W2153864507 @default.
• W2184126015 cites W2154818098 @default.
• W2184126015 cites W2157826611 @default.
• W2184126015 cites W2158864829 @default.
• W2184126015 cites W2167956058 @default.
• W2184126015 cites W2169457085 @default.
• W2184126015 cites W2174903051 @default.
• W2184126015 cites W2206542436 @default.
• W2184126015 cites W2292249227 @default.
• W2184126015 cites W2315794527 @default.
• W2184126015 cites W2011705818 @default.
• W2184126015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23504676" @default.
• W2184126015 hasPublicationYear "2013" @default.
• W2184126015 type Work @default.
• W2184126015 sameAs 2184126015 @default.
• W2184126015 citedByCount "1" @default.
• W2184126015 countsByYear W21841260152013 @default.
• W2184126015 crossrefType "journal-article" @default.
• W2184126015 hasAuthorship W2184126015A5046174197 @default.
• W2184126015 hasAuthorship W2184126015A5074483507 @default.
• W2184126015 hasConcept C121608353 @default.
• W2184126015 hasConcept C126322002 @default.
• W2184126015 hasConcept C128240485 @default.
• W2184126015 hasConcept C134018914 @default.
• W2184126015 hasConcept C170493617 @default.
• W2184126015 hasConcept C2777911890 @default.
• W2184126015 hasConcept C2779279991 @default.
• W2184126015 hasConcept C2780192828 @default.
• W2184126015 hasConcept C502942594 @default.
• W2184126015 hasConcept C61367390 @default.
• W2184126015 hasConcept C62478195 @default.
• W2184126015 hasConcept C71315377 @default.
• W2184126015 hasConcept C71924100 @default.
• W2184126015 hasConcept C7876069 @default.
• W2184126015 hasConcept C86803240 @default.
• W2184126015 hasConcept C95444343 @default.
• W2184126015 hasConceptScore W2184126015C121608353 @default.
• W2184126015 hasConceptScore W2184126015C126322002 @default.
• W2184126015 hasConceptScore W2184126015C128240485 @default.
• W2184126015 hasConceptScore W2184126015C134018914 @default.
• W2184126015 hasConceptScore W2184126015C170493617 @default.
• W2184126015 hasConceptScore W2184126015C2777911890 @default.
• W2184126015 hasConceptScore W2184126015C2779279991 @default.
• W2184126015 hasConceptScore W2184126015C2780192828 @default.

• next