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- W2184145865 abstract "Objective: The objective of this study was to evaluate the antidiabetic and hypolipidaemic activity of ethanolic root extract of Croton zambesicus in rats to ascertain its ethnomedical uses. Methods:The root of Croton zambesicus was collected, dried and extracted in ethanol. The phytochemical screening as well as determination of median lethal dose (LD ) 50 was carried out. Blood Glucose levels of alloxan-induced diabetic rats were monitored after the administration of Croton zambesicus extract (27 – 81mg/kg) to the diabetic rats for 14 days. The effects of the extract on Blood Glucose levels and lipid profile of the diabetic rats were evaluated. Results: Treatment of alloxan diabetic rats with the extract caused a significant (P<0.001) reduction in fasting blood glucose levels (BGL) of the diabetic rats both in acute study and prolonged treatment (2 weeks). The activity of the extract was comparable to that of the reference drug, glibenclamide. C. zambesicus treatment showed considerable lowering of serum total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol and an increase in HDL cholesterol in the treated diabetic group. The extract was also found to be nephroprotective in diabetic rats. Conclusion: These results suggest that the root extract of C. zambesicus possesses antidiabetic and hypolipidaemic effect on alloxan induced diabetic rats." @default.
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- W2184145865 date "2011-01-01" @default.
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- W2184145865 title "Antidiabetic and Hypolipidemic Activities of Ethanolic Root Extract of Croton zambesicus on Alloxan Induced Diabetic Rats" @default.
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