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• W2184162884 abstract "Objective: Colorectal cancer is one of the leading causes of death in the world. Plant-derived products have proven to be valuable sources for discovery and development of unique anticancer drugs. Methods: In this study, the possible therapeutic effect of rosemary (Rosmarinus officinalis L.) successive methanolic fraction on colorectal cancer induced in experimental animals was studied through several biochemical and molecular genetics analyses as well as histological investigation of colon tissue. Results: The biochemical results revealed significant elevation in serum colon cancer specific antigen-4 (CCSA-4) and carcinoembryonic antigen (CEA) in colorectal cancer induced group while programmed cell death protein-4 (PDCDP-4) and cytochrome C (CYT-C) showed significant depletion as compared to the control group. Molecular genetics results indicated that colorectal cancer induced group exhibited significant up regulation in the expression level of β-catenin, K-ras and c-myc genes in colon tissue. On the other hand, treatment with rosemary successive methanolic fraction (RSMF) could ameliorate the biochemical markers and down regulate β-catenin, K-ras and c-myc gene expression levels in colon tissue of the treated groups compared with untreated cancer induced group. These findings were greatly supported by histopathological results. Conclusion: Thus, it could be concluded that rosemary (Rosmarinus officinalis L.) has a promising therapeutic effect against colorectal cancer induced in experimental animals through its apoptotic, anti-inflammatory, and antiproliferative effects." @default.
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• W2184162884 date "2013-01-01" @default.
• W2184162884 modified "2023-09-27" @default.
• W2184162884 title "PROMISING THERAPEUTIC ROLE OF ROSMARINUS OFFICINALIS SUCCESSIVE METHANOLIC FRACTION AGAINST COLORECTAL CANCER" @default.
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