FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2184215533> ?p ?o ?g. }

• W2184215533 endingPage "3299" @default.
• W2184215533 startingPage "3293" @default.
• W2184215533 abstract "Arm protein lost in epithelial cancers, on chromosome X (ALEX) is a novel subgroup within the armadillo (ARM) family, which has one or two ARM repeat domains as opposed to more than six-thirteen repeats in the classical Armadillo family members.In the study, we explore the biological functions of ALEX1 in breast cancer cells. Overexpression of ALEX1 and silencing of ALEX1 were performed with SK-BR3 and MCF-7 cell lines. Cell proliferation and colony formation assays, along with flow cytometry, were carried out to evaluate the roles of ALEX1.ALEX1 overexpression in SK-BR3 breast cancer cells inhibited proliferation and induced apoptosis. Furthermore, depletion of ALEX1 in MCF-7 breast cancer cells increased proliferation and inhibited apoptosis. Additional analyses demonstrated that the overexpression of ALEX1 activated the intrinsic apoptosis cascades through up-regulating the expression of Bax, cytosol cytochrome c, active caspase-9 and active caspase-3 and down-regulating the levels of Bcl-2 and mitochondria cytochrome c. Simultaneouly, silencing of ALEX1 inhibited intrinsic apoptosis cascades through down-regulating the expression of Bax, cytosol cytochrome c, active caspase-9, and active caspase-3 and up-regulating the level of Bcl-2 and mitochondria cytochrome c.Our data suggest that ALEX1 as a crucial tumor suppressor gene has been involved in cell proliferation and apoptosis in breast cancer, which may serve as a novel candidate therapeutic target." @default.
• W2184215533 created "2016-06-24" @default.
• W2184215533 creator A5004676038 @default.
• W2184215533 creator A5005958218 @default.
• W2184215533 creator A5007193507 @default.
• W2184215533 creator A5007463264 @default.
• W2184215533 creator A5069161560 @default.
• W2184215533 creator A5073811582 @default.
• W2184215533 creator A5088757206 @default.
• W2184215533 date "2015-04-29" @default.
• W2184215533 modified "2023-10-16" @default.
• W2184215533 title "ALEX1 Regulates Proliferation and Apoptosis in Breast Cancer Cells" @default.
• W2184215533 cites W1968760009 @default.
• W2184215533 cites W1989168435 @default.
• W2184215533 cites W1997105701 @default.
• W2184215533 cites W2000527164 @default.
• W2184215533 cites W2003601985 @default.
• W2184215533 cites W2008292129 @default.
• W2184215533 cites W2009713979 @default.
• W2184215533 cites W2010572700 @default.
• W2184215533 cites W2032117499 @default.
• W2184215533 cites W2037156379 @default.
• W2184215533 cites W2039661491 @default.
• W2184215533 cites W2051946159 @default.
• W2184215533 cites W2071377606 @default.
• W2184215533 cites W2082387343 @default.
• W2184215533 cites W2084797469 @default.
• W2184215533 cites W2092479420 @default.
• W2184215533 cites W2095086052 @default.
• W2184215533 cites W2106787323 @default.
• W2184215533 cites W2152793164 @default.
• W2184215533 cites W2167109216 @default.
• W2184215533 cites W2170507464 @default.
• W2184215533 cites W2171836236 @default.
• W2184215533 cites W2472453408 @default.
• W2184215533 doi "https://doi.org/10.7314/apjcp.2015.16.8.3293" @default.
• W2184215533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25921134" @default.
• W2184215533 hasPublicationYear "2015" @default.
• W2184215533 type Work @default.
• W2184215533 sameAs 2184215533 @default.
• W2184215533 citedByCount "6" @default.
• W2184215533 countsByYear W21842155332017 @default.
• W2184215533 countsByYear W21842155332018 @default.
• W2184215533 countsByYear W21842155332019 @default.
• W2184215533 countsByYear W21842155332021 @default.
• W2184215533 countsByYear W21842155332022 @default.
• W2184215533 crossrefType "journal-article" @default.
• W2184215533 hasAuthorship W2184215533A5004676038 @default.
• W2184215533 hasAuthorship W2184215533A5005958218 @default.
• W2184215533 hasAuthorship W2184215533A5007193507 @default.
• W2184215533 hasAuthorship W2184215533A5007463264 @default.
• W2184215533 hasAuthorship W2184215533A5069161560 @default.
• W2184215533 hasAuthorship W2184215533A5073811582 @default.
• W2184215533 hasAuthorship W2184215533A5088757206 @default.
• W2184215533 hasBestOaLocation W21842155331 @default.
• W2184215533 hasConcept C104317684 @default.
• W2184215533 hasConcept C119056186 @default.
• W2184215533 hasConcept C153911025 @default.
• W2184215533 hasConcept C190283241 @default.
• W2184215533 hasConcept C28859421 @default.
• W2184215533 hasConcept C29311851 @default.
• W2184215533 hasConcept C31573885 @default.
• W2184215533 hasConcept C502942594 @default.
• W2184215533 hasConcept C54355233 @default.
• W2184215533 hasConcept C553184892 @default.
• W2184215533 hasConcept C62112901 @default.
• W2184215533 hasConcept C86803240 @default.
• W2184215533 hasConcept C95444343 @default.
• W2184215533 hasConcept C98424977 @default.
• W2184215533 hasConceptScore W2184215533C104317684 @default.
• W2184215533 hasConceptScore W2184215533C119056186 @default.
• W2184215533 hasConceptScore W2184215533C153911025 @default.
• W2184215533 hasConceptScore W2184215533C190283241 @default.
• W2184215533 hasConceptScore W2184215533C28859421 @default.
• W2184215533 hasConceptScore W2184215533C29311851 @default.
• W2184215533 hasConceptScore W2184215533C31573885 @default.
• W2184215533 hasConceptScore W2184215533C502942594 @default.
• W2184215533 hasConceptScore W2184215533C54355233 @default.
• W2184215533 hasConceptScore W2184215533C553184892 @default.
• W2184215533 hasConceptScore W2184215533C62112901 @default.
• W2184215533 hasConceptScore W2184215533C86803240 @default.
• W2184215533 hasConceptScore W2184215533C95444343 @default.
• W2184215533 hasConceptScore W2184215533C98424977 @default.
• W2184215533 hasIssue "8" @default.
• W2184215533 hasLocation W21842155331 @default.
• W2184215533 hasLocation W21842155332 @default.
• W2184215533 hasOpenAccess W2184215533 @default.
• W2184215533 hasPrimaryLocation W21842155331 @default.
• W2184215533 hasRelatedWork W1604961159 @default.
• W2184215533 hasRelatedWork W1965705993 @default.
• W2184215533 hasRelatedWork W19916217 @default.
• W2184215533 hasRelatedWork W2000225649 @default.
• W2184215533 hasRelatedWork W2036667953 @default.
• W2184215533 hasRelatedWork W2059092928 @default.
• W2184215533 hasRelatedWork W2073254770 @default.
• W2184215533 hasRelatedWork W2366219004 @default.
• W2184215533 hasRelatedWork W2383263084 @default.
• W2184215533 hasRelatedWork W3046665064 @default.

• next