FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2184236446> ?p ?o ?g. }

• W2184236446 endingPage "101" @default.
• W2184236446 startingPage "88" @default.
• W2184236446 abstract "The objective of this study is to investigate the sources of variability and uncertainty in a previously developed human lung dosimetry model. That three-compartment model describes the retention and clearance kinetics of respirable particles in the gas-exchange region of the lungs. It was calibrated using exposure histories and lung dust burden data in U.S. coal miners. A multivariate parameter estimation and optimization method was developed for fitting the dosimetry model to these human data. Models with various assumptions about overloading of alveolar clearance and interstitialization (sequestration) of particles were evaluated. Variability in the estimated clearance rate coefficients was assessed empirically by fitting the model to groups' and to each miner's data. Distributions of lung and lymph node particle burdens were computed at working lifetime exposures, using the variability in the estimated individual clearance rate coefficients. These findings confirm those of the earlier analysis; i.e., the best-fitting exposure-dose model to these data has substantial interstitialization/sequestration of particles and no dose-dependent decline in alveolar clearance. Among miners with different characteristics for smoking, disease, and race, the group median estimated alveolar clearance rate coefficients varied by a factor of approximately 4. Adjustment for these group differences provided some improvement in the dosimetry model fit to all miners (up to 25% reduction in MSE), although unexplained interindividual differences made up the largest source of variability. The predicted mean lung and lymph node particle burdens at age 75 after exposure to respirable coal mine dust at 2 mg/m(2) for a 45-year working lifetime were 12 g (5th and 95th percentiles, 3.0-26 g) and 1.9 g (0.26-5.3), respectively. This study provides quantitative information on variability in particle retention and clearance kinetics in humans. It is useful for risk assessment by providing estimated lung dust burdens associated with occupational exposure to respirable particles." @default.
• W2184236446 created "2016-06-24" @default.
• W2184236446 creator A5005291112 @default.
• W2184236446 creator A5010597395 @default.
• W2184236446 creator A5048783721 @default.
• W2184236446 creator A5071647048 @default.
• W2184236446 date "2001-08-01" @default.
• W2184236446 modified "2023-10-08" @default.
• W2184236446 title "A Biomathematical Model of Particle Clearance and Retention in the Lungs of Coal Miners" @default.
• W2184236446 cites W1981997555 @default.
• W2184236446 cites W1999006004 @default.
• W2184236446 cites W2000486663 @default.
• W2184236446 cites W2008878179 @default.
• W2184236446 cites W2013133700 @default.
• W2184236446 cites W2024382466 @default.
• W2184236446 cites W2037864846 @default.
• W2184236446 cites W2046833258 @default.
• W2184236446 cites W2057833737 @default.
• W2184236446 cites W2065960757 @default.
• W2184236446 cites W2071286317 @default.
• W2184236446 cites W2071366248 @default.
• W2184236446 cites W2082374195 @default.
• W2184236446 cites W2083316874 @default.
• W2184236446 cites W2090873990 @default.
• W2184236446 cites W2105859139 @default.
• W2184236446 cites W2113715883 @default.
• W2184236446 cites W2122806458 @default.
• W2184236446 cites W2133390600 @default.
• W2184236446 cites W2561283392 @default.
• W2184236446 cites W3143949042 @default.
• W2184236446 doi "https://doi.org/10.1006/rtph.2001.1480" @default.
• W2184236446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11502159" @default.
• W2184236446 hasPublicationYear "2001" @default.
• W2184236446 type Work @default.
• W2184236446 sameAs 2184236446 @default.
• W2184236446 citedByCount "28" @default.
• W2184236446 countsByYear W21842364462012 @default.
• W2184236446 countsByYear W21842364462013 @default.
• W2184236446 countsByYear W21842364462014 @default.
• W2184236446 countsByYear W21842364462015 @default.
• W2184236446 countsByYear W21842364462016 @default.
• W2184236446 countsByYear W21842364462017 @default.
• W2184236446 countsByYear W21842364462019 @default.
• W2184236446 crossrefType "journal-article" @default.
• W2184236446 hasAuthorship W2184236446A5005291112 @default.
• W2184236446 hasAuthorship W2184236446A5010597395 @default.
• W2184236446 hasAuthorship W2184236446A5048783721 @default.
• W2184236446 hasAuthorship W2184236446A5071647048 @default.
• W2184236446 hasConcept C105795698 @default.
• W2184236446 hasConcept C126322002 @default.
• W2184236446 hasConcept C161584116 @default.
• W2184236446 hasConcept C178790620 @default.
• W2184236446 hasConcept C18206936 @default.
• W2184236446 hasConcept C185592680 @default.
• W2184236446 hasConcept C2777714996 @default.
• W2184236446 hasConcept C2989005 @default.
• W2184236446 hasConcept C33923547 @default.
• W2184236446 hasConcept C39432304 @default.
• W2184236446 hasConcept C518851703 @default.
• W2184236446 hasConcept C71924100 @default.
• W2184236446 hasConcept C75088862 @default.
• W2184236446 hasConceptScore W2184236446C105795698 @default.
• W2184236446 hasConceptScore W2184236446C126322002 @default.
• W2184236446 hasConceptScore W2184236446C161584116 @default.
• W2184236446 hasConceptScore W2184236446C178790620 @default.
• W2184236446 hasConceptScore W2184236446C18206936 @default.
• W2184236446 hasConceptScore W2184236446C185592680 @default.
• W2184236446 hasConceptScore W2184236446C2777714996 @default.
• W2184236446 hasConceptScore W2184236446C2989005 @default.
• W2184236446 hasConceptScore W2184236446C33923547 @default.
• W2184236446 hasConceptScore W2184236446C39432304 @default.
• W2184236446 hasConceptScore W2184236446C518851703 @default.
• W2184236446 hasConceptScore W2184236446C71924100 @default.
• W2184236446 hasConceptScore W2184236446C75088862 @default.
• W2184236446 hasIssue "1" @default.
• W2184236446 hasLocation W21842364461 @default.
• W2184236446 hasLocation W21842364462 @default.
• W2184236446 hasOpenAccess W2184236446 @default.
• W2184236446 hasPrimaryLocation W21842364461 @default.
• W2184236446 hasRelatedWork W1972877072 @default.
• W2184236446 hasRelatedWork W2007839613 @default.
• W2184236446 hasRelatedWork W2064873898 @default.
• W2184236446 hasRelatedWork W2065864741 @default.
• W2184236446 hasRelatedWork W2068340264 @default.
• W2184236446 hasRelatedWork W2101073864 @default.
• W2184236446 hasRelatedWork W2115968180 @default.
• W2184236446 hasRelatedWork W2412325395 @default.
• W2184236446 hasRelatedWork W4205482557 @default.
• W2184236446 hasRelatedWork W4285153207 @default.
• W2184236446 hasVolume "34" @default.
• W2184236446 isParatext "false" @default.
• W2184236446 isRetracted "false" @default.
• W2184236446 magId "2184236446" @default.
• W2184236446 workType "article" @default.