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- W2184242308 abstract "Botanical dietary supplements are widely available without requirements for proof of safety or efficacy, but with requirements to be produced according to current Good Manufacturing Practices. Since 2007, cGMP’s mandated under federal law include standards for manufacture, storage and distribution and the assurance of quality and integrity of products sold to consumers. While standards require compliance with content claims made in labeling, there remain no assurances of bioavailability. Historically, feverfew is a dietary supplement taken by sufferers of migraine headaches. We examined the dissolution profiles of commercially obtained powdered feverfew products and analyzed them for the presence and quantity of parthenolide, the proposed active constituent and marker compound. Encapsulated feverfew products were purchased at local retail markets throughout metropolitan Chicago, Illinois, USA, and subjected to dissolution testing in the laboratory. Aliquots removed from testing vessels over a 2 hour period were extracted and analyzed by hplc. Analysis of each sample demonstrates whether or not parthenolide is detectable, depending on the conditions dissolution. Parthenolide in encapsulated powdered feverfew products may not withstand the extreme pH of the stomach. Therefore, it may be best to recommend that dietary supplements containing powdered feverfew be taken on an empty stomach." @default.
- W2184242308 created "2016-06-24" @default.
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- W2184242308 date "2015-07-20" @default.
- W2184242308 modified "2023-09-24" @default.
- W2184242308 title "Determination of Parthenolide from Dissolution Testing of Powdered Feverfew Products" @default.
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- W2184242308 doi "https://doi.org/10.15406/ppij.2015.02.00031" @default.
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