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- W2184245233 abstract "The present work focuses on the formulation of bilayered tablet of Metformin Hydrochloride sustained release (SR) 500 mg and Pioglitazone Hydrochloride immediate release (IR) 15mg. Sustained release matrix layer of Metformin Hydrochloride were formulated using Hydroxyl propyl methyl cellulose (HPMC K100M) and Microcrystalline cellulose (MCC PH-101) in different combinations by wet granulation technique to meet Indian Pharmacopoeia (IP) 2010 specification. Immediate release layer of Pioglitazone Hydrochloride was formulated using sodium starch glycolate (SSG) as superdisintegrant. The formulated tablets were evaluated for thickness, weight variation test, hardness test, friability test and drug content. In vitro dissolution studies were carried out in 6.8 phosphate buffer as described in the IP 2010 monograph. The kinetic modeling of in vitro dissolution profiles revealed diffusion release mechanism. The stability studies revealed no significant changes in physical and chemical properties for the optimized formulation." @default.
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- W2184245233 date "2012-01-01" @default.
- W2184245233 modified "2023-09-26" @default.
- W2184245233 title "FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE" @default.
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