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- W2184263670 abstract "Mutations in the catalytic subunit of phosphoinositide 3-kinase ( PIK3CA) and other PI3K-AKT pathway components have been associated with cancer and a wide spectrum of brain and body overgrowth. In the brain, the phenotypic spectrum of PIK3CA -related segmental overgrowth includes bilateral dysplastic megalencephaly, hemimegalencephaly and focal cortical dysplasia, the most common cause of intractable pediatric epilepsy. We generated mouse models expressing the most common activating Pik3ca mutations ( H1047R and E545K ) in developing neural progenitors. These accurately recapitulate all the key human pathological features including brain enlargement, cortical malformation, hydrocephalus and epilepsy, with phenotypic severity dependent on the mutant allele and its time of activation. Underlying mechanisms include increased proliferation, cell size and altered white matter. Notably, we demonstrate that acute 1 hr-suppression of PI3K signaling despite the ongoing presence of dysplasia has dramatic anti-epileptic benefit. Thus PI3K inhibitors offer a promising new avenue for effective anti-epileptic therapy for intractable pediatric epilepsy patients." @default.
- W2184263670 created "2016-06-24" @default.
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- W2184263670 date "2015-12-03" @default.
- W2184263670 modified "2023-10-15" @default.
- W2184263670 title "Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy" @default.
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- W2184263670 doi "https://doi.org/10.7554/elife.12703" @default.
- W2184263670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4744197" @default.
- W2184263670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26633882" @default.
- W2184263670 hasPublicationYear "2015" @default.
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