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• W2184284490 abstract "A simple class of stopping rules is introduced for time-sequential rank tests to compare to failure between two treatment groups, such as in the case of a clinical trial in which patients enter serially and in which interim analyses of the data are performed periodically so that the trial may be stopped early when one treatment is found to be significantly better than the other. These time-sequential rank tests are shown to achieve both savings in study duration and increase in power over their nonsequential counterparts, and provide a simple but statistically efficient method to circumvent the difficulty of calendar time versus information time in the design of group sequential trials with failure-time endpoints." @default.
• W2184284490 created "2016-06-24" @default.
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• W2184284490 date "1998-01-01" @default.
• W2184284490 modified "2023-09-27" @default.
• W2184284490 title "REPEATED SIGNIFICANCE TESTING WITH CENSORED RANK STATISTICS IN INTERIM ANALYSIS OF CLINICAL TRIALS" @default.
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• W2184284490 hasPublicationYear "1998" @default.
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