Matches in SemOpenAlex for { <https://semopenalex.org/work/W2184338193> ?p ?o ?g. }
- W2184338193 endingPage "1302" @default.
- W2184338193 startingPage "1297" @default.
- W2184338193 abstract "We studied the effects of maternal exposure to endotoxin on pregnancy outcome, stimulation of the hypothalamo-hypophyseal-adrenal axes (HHAA) of ewes and their fetuses, and maternal production of tumor necrosis factor alpha (TNF alpha), a central mediator in the pathogenesis of bacterial endotoxemia. Either endotoxin (lipopolysaccharide, LPS) from Salmonella typhimurium or saline was administered to pregnant sheep (n = 10) at 137.6 +/- 3.5 days gestational age by slow i.v. infusion at 1 microgram.kg-1 total dose over a 3-h period. Fetuses of ewes treated with LPS became hypoxemic by 2.5 h after initiation of LPS infusion. Maternal ACTH increased and peaked during LPS administration to levels approximately 10-fold greater in treated than in control ewes. In contrast, fetal ACTH levels were maximum at 6-12 h. Maternal and fetal cortisol levels were significantly different from control levels by 1 and 12 h, respectively. Maternal plasma TNF alpha peaked (6-7-fold over baseline) at 1-2 h after initiation of LPS administration and steadily declined over the following 48 h. Four of 5 treated ewes either delivered or their fetuses died within 28 h. In summary, infusion of LPS caused fetal hypoxemia and stimulated both fetal and maternal HHAA followed by preterm labor by 28 h after infusion in 4 of 5 ewes. Three of the fetuses died in utero. Maternal plasma TNF alpha rose rapidly, but the specific role it may play in initiation of preterm labor remains to be elucidated." @default.
- W2184338193 created "2016-06-24" @default.
- W2184338193 creator A5025533199 @default.
- W2184338193 creator A5058113223 @default.
- W2184338193 creator A5069145317 @default.
- W2184338193 creator A5071279756 @default.
- W2184338193 creator A5086443525 @default.
- W2184338193 creator A5089268194 @default.
- W2184338193 date "1994-06-01" @default.
- W2184338193 modified "2023-09-23" @default.
- W2184338193 title "Effect of Salmonella Endotoxin Administered to the Pregnant Sheep at 133–142 Days Gestation on Fetal Oxygenation, Maternal and Fetal Adrenocorticotropic Hormone and Cortisol, and Maternal Plasma Tufnor Necrosis Factor α Concentrations1" @default.
- W2184338193 cites W115982262 @default.
- W2184338193 cites W127414004 @default.
- W2184338193 cites W136462 @default.
- W2184338193 cites W1500619809 @default.
- W2184338193 cites W1545267380 @default.
- W2184338193 cites W1588700170 @default.
- W2184338193 cites W163030697 @default.
- W2184338193 cites W1727841989 @default.
- W2184338193 cites W1860878305 @default.
- W2184338193 cites W1965897259 @default.
- W2184338193 cites W1972993926 @default.
- W2184338193 cites W1984845732 @default.
- W2184338193 cites W1989683270 @default.
- W2184338193 cites W1992482420 @default.
- W2184338193 cites W1995449190 @default.
- W2184338193 cites W2003543263 @default.
- W2184338193 cites W2007409501 @default.
- W2184338193 cites W2010909983 @default.
- W2184338193 cites W2029042181 @default.
- W2184338193 cites W2029116554 @default.
- W2184338193 cites W2029157767 @default.
- W2184338193 cites W2031689353 @default.
- W2184338193 cites W2032022513 @default.
- W2184338193 cites W2036705392 @default.
- W2184338193 cites W2045694277 @default.
- W2184338193 cites W2048540725 @default.
- W2184338193 cites W2050400746 @default.
- W2184338193 cites W2063182519 @default.
- W2184338193 cites W2073840649 @default.
- W2184338193 cites W2087605866 @default.
- W2184338193 cites W2088786274 @default.
- W2184338193 cites W2093782142 @default.
- W2184338193 cites W2095508943 @default.
- W2184338193 cites W2100451664 @default.
- W2184338193 cites W2107825638 @default.
- W2184338193 cites W2123499253 @default.
- W2184338193 cites W2128801555 @default.
- W2184338193 cites W2174322658 @default.
- W2184338193 cites W2290196379 @default.
- W2184338193 cites W2339073512 @default.
- W2184338193 cites W2339460521 @default.
- W2184338193 cites W2395242363 @default.
- W2184338193 cites W2396929965 @default.
- W2184338193 cites W2397013371 @default.
- W2184338193 cites W2397469538 @default.
- W2184338193 cites W2401672077 @default.
- W2184338193 cites W2410325753 @default.
- W2184338193 cites W2426290138 @default.
- W2184338193 cites W2618324011 @default.
- W2184338193 cites W1532470613 @default.
- W2184338193 doi "https://doi.org/10.1095/biolreprod50.6.1297" @default.
- W2184338193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8080916" @default.
- W2184338193 hasPublicationYear "1994" @default.
- W2184338193 type Work @default.
- W2184338193 sameAs 2184338193 @default.
- W2184338193 citedByCount "47" @default.
- W2184338193 countsByYear W21843381932012 @default.
- W2184338193 countsByYear W21843381932013 @default.
- W2184338193 countsByYear W21843381932014 @default.
- W2184338193 countsByYear W21843381932015 @default.
- W2184338193 countsByYear W21843381932016 @default.
- W2184338193 countsByYear W21843381932017 @default.
- W2184338193 countsByYear W21843381932020 @default.
- W2184338193 countsByYear W21843381932022 @default.
- W2184338193 crossrefType "journal-article" @default.
- W2184338193 hasAuthorship W2184338193A5025533199 @default.
- W2184338193 hasAuthorship W2184338193A5058113223 @default.
- W2184338193 hasAuthorship W2184338193A5069145317 @default.
- W2184338193 hasAuthorship W2184338193A5071279756 @default.
- W2184338193 hasAuthorship W2184338193A5086443525 @default.
- W2184338193 hasAuthorship W2184338193A5089268194 @default.
- W2184338193 hasBestOaLocation W21843381931 @default.
- W2184338193 hasConcept C126322002 @default.
- W2184338193 hasConcept C134018914 @default.
- W2184338193 hasConcept C172680121 @default.
- W2184338193 hasConcept C17991360 @default.
- W2184338193 hasConcept C201614185 @default.
- W2184338193 hasConcept C2776953305 @default.
- W2184338193 hasConcept C2778376644 @default.
- W2184338193 hasConcept C2778754761 @default.
- W2184338193 hasConcept C2779234561 @default.
- W2184338193 hasConcept C2779753670 @default.
- W2184338193 hasConcept C2780546910 @default.
- W2184338193 hasConcept C46973012 @default.
- W2184338193 hasConcept C54355233 @default.
- W2184338193 hasConcept C71315377 @default.
- W2184338193 hasConcept C71924100 @default.