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- W2184351886 abstract "The present study was undertaken to determine the anti-ulcer potential and antisecretory properties of the Methanol extract of Pongamia Pinnata root Extract with relation to in vitro anti-oxidant studies. Methanol extracts of the root P. Pinnata were tested orally at the doses of 15, 20 and 25 mg/kg, on gastric ulcerations experimentally induced by aspirin, alcohol and pylorus ligation models. The extract at the dose of 25 mg/kg showed 79.30 and 82.20 % inhibition when gastric ulcerations were induced by aspirin and ethanol and 66.38 % inhibition showed in pylorus ligation at a dose of 20 mg/kg respectively. The methanol extract at 20 and 25 mg/kg was showed significantly (P<0.001) inhibited ulcer formation. Methanol extract which contains flavonoids, triterpenes, carotinoids and saponins, which may exhibited an anti-ulcer properties. To understand the pharmacological actions, in vitro anti-oxidant activity of Methanol extract of the root P. Pinnata was investigated for activity of scavenging lipid peroxidation, reducing power, superoxide anion radicals and hydroxyl radical. In all the testing, a significant correlation existed between concentration of the extract and percentage of inhibition of free radicals. The extract inhibited 72.47, 75.86, 68.11 and 77.46 % on lipid per oxidation, reducing power, superoxide anion and hydroxyl radical scavenging activity at a 50 µg/ml concentration respectively. The anti-oxidant property may be related to the flavonoids and polyphenol present in the extract. These results clearly indicated that Methanol extract of the root P. Pinnata is effective against free radical mediated ulcer disease." @default.
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- W2184351886 date "2010-01-01" @default.
- W2184351886 modified "2023-09-23" @default.
- W2184351886 title "Anti-ulcer and anti- secretory properties of the Pongamia pinnata root extract with relation to antioxidant studies." @default.
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