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- W2184387302 abstract "Erythrocyte Binding Antigen-175 (EBA-175) represents one of the most important ligands mediating erythrocyte invasion and has become the target of various studies in attempts to obtain a suitable vaccine candidate. Previous studies reported that the eba-175 gene have two dimorphic alleles that were characterized by nucleotide insertion of either a 342 bp segment in FCR-3 strain (F-segment) or a 423 bp segment in CAMP strains (C- segment). The Moleculer Epidemiologic studies to determine the frequency distribution of C and F segments in various malaria endemic areas and associated with clinical manifestation was conducted in three sub-districts of Jayapura. The aim of the present study was to determine the frequency distribution of dimorphic allele of eba-175 gene among the clinically asymptomatic and symptomatic falciparum malaria cases in Jayapura District. From PCR analyzed eba-175 gene obtained in 110 asymptomatic and 100 symptomatic subjects indicate that the C segment was the dominant in both groups, with the frequency distribution in asymptomatic malaria was 62.7% of C segment and 18.2% of F segment and 19.1% of mixture of C and F. In symptomatic malaria cases, the frequency distribution was 55% for C segment and 37% for F segment and 8% mixture of C and F. Statistical analysis using Chi-square revealed no specific correlation between the eba-175 segments with the clinical manifestation of malaria. This study identified several malaria endemic areas in Jayapura district, Papua Province, Indonesia. Moleculer analyses of the P. falciparum isolates demonstrated that the C segment of eba-175 gene is dominant but no signicant correlation was found between the allelic frequency of eba-175 gene with the clinical manifestation as well as severity of the disease." @default.
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- W2184387302 date "2012-01-01" @default.
- W2184387302 modified "2023-09-27" @default.
- W2184387302 title "Allele Dimorphic of Eba-175 gene of Plasmodium falciparum and Associated with Clinical Manifestation in Jayapura District, Papua, Indonesia" @default.
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