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- W2184450543 abstract "Introduction In the absence of randomised trials making head-to-head comparisons, we wanted to evaluate the pain- reducing effect of glucosamine hydro- chloride (GH) and the use of the Rosa canina (RP) therapy in patients with osteoarthritis by using an indirect comparison meta-analysis. Materials and methods Randomised controlled trials includ- ed in published meta-analyses were eligible for inclusion. The standard- ised mean difference (SMD) was used as an effective measure, and the difference between GH and RP was calculated using the Bucher approach. Results There was no heterogeneity for any nutraceuticals. GH studies were consist- ently located around an effect size of zero (SMD = -0.01 (-0.14; -0.12)), whereas RP studies consistently pointed towards an effect size of 0.4 (SMD = -0.37 (-0.60; -0.13)). Testing whether there was any significant difference between GH and RP (both in contrast to placebo), we applied the Bucher approach, which resulted in an effect size of 0.36 in favour of RP (SMD = 0.36 (0.09 ; 0.62), Z = 2.65; P = 0.0082). Conclusion" @default.
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- W2184450543 date "2013-01-01" @default.
- W2184450543 modified "2023-09-22" @default.
- W2184450543 title "Superiority trials in osteoarthritis using glucosamine hydrochloride as comparator: an overview of reviews and indirect comparison with Rosa canina" @default.
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