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- W2184491044 abstract "ABSTRACT Theadditionofnaturallyoccurringpolyaminesandinorganic ions to anin vitro protein-synthesizing systemimprovedtheextentandfidelityoftranslation. Insuchanop-timized system,regeneration ofthe nucleoside triphosphateswithphosphoenolpyruvate andpyruvatekinase(ATP:pyruvate 2-O-phosphotransferase, EC2.7.1.40)reducedfurtherthemis-senseerrorfrequencytothe in vivolevel aswellasenhancedtheextentoftranslation. Theeffectofnucleosidetriphosphateregenerationwasshowntobedueprimarilytotheincreaseinthe ratio of adenosine and guanosine triphosphates to theirhydrolysisproductsandonlymarginallyduetotheincreaseintheabsoluteconcentrations ofthenucleosidetriphosphates.The frequency ofmissenseerrorsoftranslationduringinvmvoprotein synthesis is approximately 1 in 10,000 (1-8). Incontrast,in vitro translation systems generallyyield missenseerrorsat frequenciesthat are ordersofmagnitudehigher(4-6). Clearly,the relevant biochemical preparations are not functioningproperly invitro, andthis inturn hampers attemptstoelucidate" @default.
- W2184491044 created "2016-06-24" @default.
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- W2184491044 date "1979-01-01" @default.
- W2184491044 modified "2023-09-27" @default.
- W2184491044 title "Nucleoside triphosphate regeneration decreases thefrequency of translation errors (protein synthesis/polyamines/calcium/phosphoenolpyruvate/missense errors)" @default.
- W2184491044 hasPublicationYear "1979" @default.
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