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• W2184508663 abstract "AIm: We hypothesized that the loss of structural integrity in vessels of brain arteriovenous malformations (bAVM) is associated with abnormal expression of collagen subtypes. mAterIAl and methOds: We retrospectively obtained the nidus tissue specimens from 24 bAVM patients and structurally normal cerebral cortex from six surgical epilepsy patients. The samples were paraffin-embedded and stained with Victoria blue and picrosirius red and examined by light microscopy. results: Light microscopy showed that collagen fibers became disorganized, and the internal elastic lamina was duplicated or interrupted in the arteries from the nidus tissue of bAVM. In some vessels in the nidus, Col I was the only collagen component and the interstitial tissue was mainly comprised of Col I. bAVM patients showed significantly higher Col I levels (86.25% ±13.92) and lower Col III levels (13.75% ±13.92) in the vasculature in the nidus tissue than those of otherwise normal surgical epilepsy patients (Col I, 80.78% ±18.03; Col III, 19.22% ±18.03) (p<0.001). Additionally, bAVM patients showed a higher Col I / Col III ratio (24.71±40.47) than that of normal controls (16.04 ±31.28) (p<0.001). COnClusIOn: bAVM patients exhibit changes in the Col I/Col III ratio and elastic fibers in the vasculature, which may compromise the structural integrity of cerebral vessels. Keyw Ords: Arteriovenous malformation, Collagen, Elastic fibers" @default.
• W2184508663 created "2016-06-24" @default.
• W2184508663 creator A5026901954 @default.
• W2184508663 creator A5062879756 @default.
• W2184508663 date "2013-01-01" @default.
• W2184508663 modified "2023-09-26" @default.
• W2184508663 title "human Brain Arteriovenous Malformations are Associated with Interruptions in elastic Fibers and Changes in Collagen Content İnsan Beyin Arteriövenöz Malformasyonlari Elastik Liflerde Kesintiler ve Kollajen İçeriğinde Değişikliklerle İlişkilidir" @default.
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