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- W2184518503 abstract "Escitalopram oxalate was shown to inhibit the in vitro growth of microbial infections. Generally Escitalopram used in the treatment of depression, but having other pharmacological action of antimicrobial activity. A total of five strains were studied to determine whether the anti depressant drug Escitalopram used in combination with the conventional antibiotic Gentamycin and Ciprofloxacin synergistically augments the efficacy of the antibiotic in vitro. The effect of combination was evaluated by MIC determination by turbidity method and disc diffusion method Escitalopram was synergistic with Gentamycin and Ciprofloxacin against tested organisms Gram-positive clinical isolates like staphylococcus aureus NCIM 2079, Gram-negative organisms such as pseudomonas aeruginosa NCIM 2036, klebsiella pneumonia NCIM 2719, proteus mirabilis, enterobator cloacae NCIM 2164. From the results of MIC Escitalopram oxalate against staph aureus 1000 µg/ml, enterococcus faecalis is 1000 µg/ml, pseudo flatulence1000 µg/ml, Klebsiella pneumonia 250 µg/ml, proteus mirabilis 500 µg/ml whereas in combination there was two, three fold reduction of MIC. Thus, the ability of extended antibiotic therapy may be improved with the help of this synergistic drug pair in micro organisms. The Significance of such findings may indicate parallel administration of antidepressant with antibiotics against micro organisms." @default.
- W2184518503 created "2016-06-24" @default.
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- W2184518503 date "2013-01-01" @default.
- W2184518503 modified "2023-09-27" @default.
- W2184518503 title "Efficacy of Antibacterial Activity of Antibiotics Ciprofloxacin and Gentamycin Improved with Anti Depressant Drug, Escitalopram" @default.
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