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- W2184520112 abstract "Summary Objectives: We aimed to determine the eff ects of intraperitoneal administration of levobupivacaine on pain after laparoscopic cholecystectomy in a prospective, randomized, double-blinded, placebo-controlled trial. Methods: In all patients, infi ltration of levobupivacaine 0.25% (15 mL) was used prior to skin incisions for trocar insertion. After pneumoperitoneum was achieved, patients were allocated randomly to receive intraperitoneally either 40 mL of 0.25% levobupivacaine (LB group, n=20) or normal saline (NS group, n=20) under direct vision into the hepatodiaphragmatic lodge and above the gallbladder. Data of intraoperative variables, postoperative pain relief, rescue analgesic consumption, side effects, and patient satisfaction were followed in both groups. Results: Th e postoperative pain scores were signifi cantly lower in the fi rst half-hour period in the LB group than in the NS group (p<0.05). However, the incidence of right shoulder pain was not signifi cantly diff erent between the LB group (10%) and NS group (15%). Th e mean dose of meperidine consumption and the number of patients needing rescue meperidine were signifi cantly lower in the LB group than in the NS group (p<0.05). Signifi cantly lower vomiting incidence and increased patient satisfaction were determined in the LB group compared to the NS group (p<0.05). Conclusion: Intraperitoneal administration of 40 mL levobupivacaine 0.25% given immediately after pneumoperitoneum into the hepatodiaphragmatic lodge and above the gallbladder demonstrated useful eff ects on postoperative pain relief after laparoscopic cholecystectomy, especially in the early postoperative period, and reduced postoperative rescue analgesic requirement, with excellent patient satisfaction. Th ere were no LB-related complications or side eff ects." @default.
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- W2184520112 date "2009-01-01" @default.
- W2184520112 modified "2023-09-27" @default.
- W2184520112 title "Effects of intraperitoneal levobupivacaine on pain after laparoscopic cholecystectomy: a prospective, randomized, double-blinded study İntraperitoneal levobupivakain uygulamasinin laparoskopik kolesistektomi sonrasi ağri üzerine etkisi: Prospektif, randomize, çift-kör çalişma" @default.
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