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- W2184536057 abstract "Objective-To investigate thetransfer of autoimnmunity byallogenic bonemarrow transplantation. Methods-Bonemarrow transplantation was performed ina 43years oldman with acutemyeloid leukaemia (AML)inremission.The donorwas hisHLA identical brotherwho had a mildsystemic lupus erythematosus (SLE).Autoantibodies, including antinuclear, anti-Clq, andanticardiolipin antibodies, were measured beforeandafter transplantation. Results-Transient mildgraft versus host disease (GvHD)developed intherecipient in theweeksfollowing transplantation. Thedonorhadpersistently highconcentrations ofanti-Clq antibodies tothecollagenousregionof the complement component Clq. Three months after transplantation therecipient developed antiClqantibodies thatpersisted fortwo months.No otherautoantibodies andno SLE-like manifestationsappeared. ChronicGVHD startedfivemonths posttransplant andresponded tointensified immunosuppressive treatment.Three years post-transplant thepatient was in unmaintainedremission. Withina few weeksafterbone marrow donationthe donor' s diseasewas exacerbatedwith development ofsevere pulmonary alveolitis which requiredtreatment with cyclophosphamide. Conclusions-When bonemarrow transplantation was performedin a patient withAML withbone marrow from an HLA identical brotherwho had SLE,no evidenceof transferof diseasewas obtained. However,therecipient temporarilyproducedanti-Clqantibodies whichwas a characteristic feature ofthe donor' s SLE andwas probably produced bythetransplant. Theflareofthedonor's SLE mightberelated tothebonemarrow" @default.
- W2184536057 created "2016-06-24" @default.
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- W2184536057 date "1996-01-01" @default.
- W2184536057 modified "2023-09-27" @default.
- W2184536057 title "Transplantation withallogenic bonemarrow from adonorwithsystemic lupus erythematosus (SLE): successful outcomeintherecipient andinduction ofan SLEflare inthedonor" @default.
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