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- W2184564243 abstract "Ionization constant (pKa) is one among the parameter to be estimated with accuracy, irrespective of solubility constraints. In the present study, acid-base behaviour of the piroxicam and tenoxicam was studied. By using the potentiometric method, pKa values of piroxicam and tenoxicam have been determined in different percentage of acetonitrile-water binary mixtures (acetonitrile content between 30 and 45% in volume). Aqueous pKa values of these compounds were calculated by mole fraction and Yasuda-Shedlovsky equations. The experimental pKa values were compared to the corresponding predicted values derived by SPARC and Marvin Sketch software packages." @default.
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- W2184564243 date "2012-06-04" @default.
- W2184564243 modified "2023-09-23" @default.
- W2184564243 title "Potentiometric pKa Determination of Piroxicam and Tenoxicam in Acetonitrile-Water Binary Mixtures" @default.
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