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• W2184589236 abstract "This study aimed to investigate the influence of formulation factors on the physico-chemical properties of quercetin-loaded liposomes and optimize the preparation conditions. An experimental design with three factors and three levels was used. The variables were dipalmitoylphosphatidylcholine (DPPC) concentration, DPPC:Cholesterol (CHOL) molar ratio and quercetin (QU) concentration. The responses were the mean diameter, polydispersity index (PdI) and drug encapsulation efficiency. All samples were prepared according to the experimental design matrix consisting of 17 experiments. Results showed that DPPC concentration and DPPC:CHOL molar ratio had a strong influence on liposome size and PdI. Higher DPPC concentrations led to larger particles and PdI values, but a further increase of DPPC concentration produced a reduction in size and lower PdI. Increasing the lipid ratio caused a decrease in size, but a somewhat higher PdI. QU concentration only slightly influenced particle size and PdI. The degree of QU loading depended on the factors assessed. Increasing DPPC concentration and lipid ratio significantly enhanced QU entrapment. However, higher QU concentrations had a negative effect on drug entrapment. Based on this, an optimized formulation was determined, prepared and analysed. The overall results showed that DPPC concentration and lipid ratio were the main factors influencing particle size, while entrapment efficiency was affected predominantly by QU concentration. Rezumat Acest studiu a urmarit influența factorilor de formulare asupra unei metode de preparare a lipozomilor și optimizarea condițiilor de preparare a lipozomilor cu cvercetina. A fost utilizat un plan experimental cu trei factori și trei niveluri. Factorii au fost concentrația de dipalmitoilfosfatidilcolina (DPPC), raportul molar DPPC:Colesterol (CHOL) și concentrația de cvercetina (QU). Raspunsurile au fost diametrul mediu, indicele de polidispersie (PdI) și eficiența incorporarii. Probele au fost preparate conform matricei planului experimental ce a cuprins 17 experimente. Conform rezultatelor, concentrația DPPC și raportul molar DPPC:CHOL au influențat puternic diametrul și PdI. Creșterea concentrației DPPC a condus la dimensiuni și PdI mai mari, insa creșterea suplimentara a concentrației DPPC a determinat reducerea acestora. Prin creșterea raportului lipidelor s-a produs reducerea dimensiunii și creșterea ușoara a PdI. Concentrația QU nu a influențat semnificativ diametrul și PdI. Eficiența incorporarii a fost influențata de factorii analizați. Prin creșterea concentrației DPPC și raportului lipidelor a fost imbunatațita eficiența incorporarii. Totuși, creșterea concentrației QU a avut un efect negativ asupra incapsularii substanței. Pe baza acestora, a fost stabilita, preparata și analizata o formulare optimizata. Per ansamblu, rezultatele obținute au indicat ca principalii factori ce au influențat dimensiunea particulelor au fost concentrația DPPC și raportul lipidelor, in timp ce eficiența incorporarii a fost afectata in special de concentrația QU." @default.
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• W2184589236 date "2015-01-01" @default.
• W2184589236 modified "2023-09-27" @default.
• W2184589236 title "QUERCETIN-LOADED LIPOSOMES: FORMULATION OPTIMIZATION THROUGH A D-OPTIMAL EXPERIMENTAL DESIGN" @default.
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