FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2184597009> ?p ?o ?g. }

• W2184597009 endingPage "658" @default.
• W2184597009 startingPage "643" @default.
• W2184597009 abstract "Na channels open upon depolarization but then enter inactivated states from which they cannot readily reopen. After brief depolarizations, native channels enter a fast-inactivated state from which recovery at hyperpolarized potentials is rapid (< 20 ms). Prolonged depolarization induces a slow-inactivated state that requires much longer periods for recovery (> 1 s). The slow-inactivated state therefore assumes particular importance in pathological conditions, such as ischemia, in which tissues are depolarized for prolonged periods. While use-dependent block of Na channels by local anesthetics has been explained on the basis of delayed recovery of fast-inactivated Na channels, the potential contribution of slow-inactivated channels has been ignored. The principal (alpha) subunits from skeletal muscle or brain Na channels display anomalous gating behavior when expressed in Xenopus oocytes, with a high percentage entering slow-inactivated states after brief depolarizations. This enhanced slow inactivation is eliminated by coexpressing the alpha subunit with the subsidiary beta 1 subunit. We compared the lidocaine sensitivity of alpha subunits expressed in the presence and absence of the beta 1 subunit to determine the relative contributions of fast-inactivated and slow-inactivated channel block. Coexpression of beta 1 inhibited the use-dependent accumulation of lidocaine block during repetitive (1-Hz) depolarizations from -100 to -20 mV. Therefore, the time required for recovery from inactivated channel block was measured at -100 mV. Fast-inactivated (alpha + beta 1) channels were mostly unblocked within 1 s of repolarization; however, slow-inactivated (alpha alone) channels remained blocked for much longer repriming intervals (> 5 s). The affinity of the slow-inactivated state for lidocaine was estimated to be 15-25 microM, versus 24 microM for the fast-inactivated state. We conclude that slow-inactivated Na channels are blocked by lidocaine with an affinity comparable to that of fast-inactivated channels. A prominent functional consequence is potentiation of use-dependent block through a delay in repriming of lidocaine-bound slow-inactivated channels." @default.
• W2184597009 created "2016-06-24" @default.
• W2184597009 creator A5009404984 @default.
• W2184597009 creator A5018980751 @default.
• W2184597009 creator A5027864628 @default.
• W2184597009 creator A5046381230 @default.
• W2184597009 creator A5079196314 @default.
• W2184597009 date "1996-05-01" @default.
• W2184597009 modified "2023-09-23" @default.
• W2184597009 title "Functional consequences of lidocaine binding to slow-inactivated sodium channels." @default.
• W2184597009 cites W1964861261 @default.
• W2184597009 cites W1967204209 @default.
• W2184597009 cites W1968903551 @default.
• W2184597009 cites W1974794546 @default.
• W2184597009 cites W1985146688 @default.
• W2184597009 cites W1985940938 @default.
• W2184597009 cites W1993584057 @default.
• W2184597009 cites W2003360892 @default.
• W2184597009 cites W2012081623 @default.
• W2184597009 cites W2018812718 @default.
• W2184597009 cites W2019208599 @default.
• W2184597009 cites W2025002158 @default.
• W2184597009 cites W2029255000 @default.
• W2184597009 cites W2054750757 @default.
• W2184597009 cites W2069884282 @default.
• W2184597009 cites W2070233250 @default.
• W2184597009 cites W2070676751 @default.
• W2184597009 cites W2073892495 @default.
• W2184597009 cites W2074589363 @default.
• W2184597009 cites W2077585013 @default.
• W2184597009 cites W2083298157 @default.
• W2184597009 cites W2087306949 @default.
• W2184597009 cites W2091373010 @default.
• W2184597009 cites W2112571943 @default.
• W2184597009 cites W2115052737 @default.
• W2184597009 cites W2116411564 @default.
• W2184597009 cites W2125499229 @default.
• W2184597009 cites W2125875893 @default.
• W2184597009 cites W2158169241 @default.
• W2184597009 cites W2165071497 @default.
• W2184597009 cites W2165830038 @default.
• W2184597009 cites W2171411680 @default.
• W2184597009 cites W2172225359 @default.
• W2184597009 cites W2271846309 @default.
• W2184597009 doi "https://doi.org/10.1085/jgp.107.5.643" @default.
• W2184597009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2217016" @default.
• W2184597009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8740377" @default.
• W2184597009 hasPublicationYear "1996" @default.
• W2184597009 type Work @default.
• W2184597009 sameAs 2184597009 @default.
• W2184597009 citedByCount "69" @default.
• W2184597009 countsByYear W21845970092012 @default.
• W2184597009 countsByYear W21845970092013 @default.
• W2184597009 countsByYear W21845970092014 @default.
• W2184597009 countsByYear W21845970092015 @default.
• W2184597009 countsByYear W21845970092016 @default.
• W2184597009 countsByYear W21845970092017 @default.
• W2184597009 countsByYear W21845970092018 @default.
• W2184597009 countsByYear W21845970092019 @default.
• W2184597009 countsByYear W21845970092021 @default.
• W2184597009 countsByYear W21845970092022 @default.
• W2184597009 countsByYear W21845970092023 @default.
• W2184597009 crossrefType "journal-article" @default.
• W2184597009 hasAuthorship W2184597009A5009404984 @default.
• W2184597009 hasAuthorship W2184597009A5018980751 @default.
• W2184597009 hasAuthorship W2184597009A5027864628 @default.
• W2184597009 hasAuthorship W2184597009A5046381230 @default.
• W2184597009 hasAuthorship W2184597009A5079196314 @default.
• W2184597009 hasBestOaLocation W21845970091 @default.
• W2184597009 hasConcept C104292427 @default.
• W2184597009 hasConcept C104317684 @default.
• W2184597009 hasConcept C12554922 @default.
• W2184597009 hasConcept C146403970 @default.
• W2184597009 hasConcept C169760540 @default.
• W2184597009 hasConcept C178790620 @default.
• W2184597009 hasConcept C185263204 @default.
• W2184597009 hasConcept C185592680 @default.
• W2184597009 hasConcept C194544171 @default.
• W2184597009 hasConcept C4141045 @default.
• W2184597009 hasConcept C50952357 @default.
• W2184597009 hasConcept C537181965 @default.
• W2184597009 hasConcept C55493867 @default.
• W2184597009 hasConcept C86803240 @default.
• W2184597009 hasConceptScore W2184597009C104292427 @default.
• W2184597009 hasConceptScore W2184597009C104317684 @default.
• W2184597009 hasConceptScore W2184597009C12554922 @default.
• W2184597009 hasConceptScore W2184597009C146403970 @default.
• W2184597009 hasConceptScore W2184597009C169760540 @default.
• W2184597009 hasConceptScore W2184597009C178790620 @default.
• W2184597009 hasConceptScore W2184597009C185263204 @default.
• W2184597009 hasConceptScore W2184597009C185592680 @default.
• W2184597009 hasConceptScore W2184597009C194544171 @default.
• W2184597009 hasConceptScore W2184597009C4141045 @default.
• W2184597009 hasConceptScore W2184597009C50952357 @default.
• W2184597009 hasConceptScore W2184597009C537181965 @default.
• W2184597009 hasConceptScore W2184597009C55493867 @default.
• W2184597009 hasConceptScore W2184597009C86803240 @default.
• W2184597009 hasIssue "5" @default.

• next