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- W2184635518 abstract "Type 2 diabetes is an established risk factor for car-diovascular disease (CVD). Compared to non-diabetic subjects, patients with type 2 diabetes have a 2 to 4-fold increased risk of development of CVD [1]. Intensive glycemic control aiming at HbA1c below 7% has been shown to reduce the risk of development of microvas-cular disease in patients with type 2 diabetes; however, its effect on CVD was rather modest [2].Moreover, recent trials aiming to achieve near-normal glycemic control (i.e., HbA1c below 6%) to improve CVD outcomes in patients with type 2 diabetes failed to show a reduction of the primary endpoints (death from CVD, non-fatal myocardial infarct and non-fa-tal stroke) by intensive glycemic control compared to standard care [3-5]. The findings revealed a modest ef-fect of glycemic control on CVD outcome, and un-derpinned the importance of avoiding hypoglycemia in the treatment of type 2 diabetes, but also suggested the limitation of HbA1c as a predictor of therapeutic effect on CVD outcome.Glycated albumin (GA) is a ketoamine which is formed by binding of albumin and glucose by nonenzymatic glycation reaction. Since the turnover of albumin is relatively short, GA reflects the average glucose value in the previous 1 to 2 weeks, whereas HbA1c reflects the average glucose value in the previous 1 to 2 months [6]. Moreover, it has been reported that albumin is more rapidly glycated compared to hemoglobin [7]. Therefore, glycated albumin may reflect glycemic con-trol more sensitively than does HbA1c.A recently-developed enzyme method for measure-ment of GA has allowed GA to be more rapidly and easily determined [8]. Recent studies have shown that GA is more strongly correlated with postprandial gly-cemic excursion compared with HbA1c [9-12]. Since postprandial glycemic excursion has been shown to be a risk factor for CVD [13-14], GA may predict CVD outcome more sensitively than does HbA1c.This was shown to be the case. It has been reported that GA was more strongly associated with coronary atherosclerosis [15-16]. It has been also reported that GA and GA to HbA1c ratio but not HbA1c predict-" @default.
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- W2184635518 date "2013-10-31" @default.
- W2184635518 modified "2023-10-16" @default.
- W2184635518 title "Glycated Albumin: A More Sensitive Predictor of Cardiovascular Disease than Glycated Hemoglobin?" @default.
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- W2184635518 doi "https://doi.org/10.19070/2328-353x-130004e" @default.
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