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• W2184683604 abstract "Al arge corpus of research indicates that exposure to stress impairs cognitive abilities, specifically executive functioning dependent on the prefrontalcortex(PFC).WecollectedstructuralMRIscans(n!61),well-validatedassessmentsofexecutivefunctioning,anddetailedinterviews assessingstressexposureinhumanstoexaminewhethercumulativelifestressaffectedbrainmorphometryandonetypeofexecutivefunctioning, spatial working memory, during adolescence—a critical time of brain development and reorganization. Analysis of variations in brain structurerevealedthatcumulativelifestressandspatialworkingmemorywererelatedtosmallervolumesinthePFC,specificallyprefrontalgray and white matter between the anterior cingulate and the frontal poles. Mediation analyses revealed that individual differences in prefrontal volumesaccountedfortheassociationbetweencumulativelifestressandspatialworkingmemory.Theseresultssuggestthatstructuralchanges inthePFCmayserveasamediatingmechanismthroughwhichgreatercumulativelifestressengendersdecrementsincognitivefunctioning." @default.
• W2184683604 created "2016-06-24" @default.
• W2184683604 creator A5007479521 @default.
• W2184683604 date "2012-01-01" @default.
• W2184683604 modified "2023-09-27" @default.
• W2184683604 title "StructuralVariationsinPrefrontalCortexMediatethe RelationshipbetweenEarlyChildhoodStressandSpatial WorkingMemory" @default.
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