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• W2184690298 abstract "The colon targeted matrix tablet of satranidazole which is composed of polysaccharides which are susceptible to enzymatic degradation i.e. Guar gum, Xanthan gum, Guar : Xanthan gum in combination at 2 ratios (1:1) and (2:1) and Pectin coated with enteric polymer Eudragit L, Eudragit S and Eudragit RS. The SF7 formulation was found to be able, to release up to 92% of drug into colon. PVP K 30 was used as binder to fabricate a tablet having desired release characteristics. MCC was used as diluent in formulation. Coating materials used were Eudragit L, Eudragit S and Eudragit RS. As the requirement of formulation to bypass the release in stomach and small intestine Eudragit L, Eudragit S and Eudragit RS was suitable polymer in combination. Tablets coated with Eudragit L, Eudragit S and Eudragit RS in ratio of 4:16:5 with less quantity of plasticizer PEG 400 showed excellent film properties and were able to release most of the drug into colon. 10% of coating was found to be optimum. Formulation SF7 was considered as optimum batch as it delivered 96 % of drug into colon. The formulation SF7 can be employed as a promising colon specific drug delivery system of satranidazole." @default.
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• W2184690298 date "2013-01-01" @default.
• W2184690298 modified "2023-09-23" @default.
• W2184690298 title "An Investigation on Colon Drug Delivery System for Satranidazole Tablet" @default.
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