Matches in SemOpenAlex for { <https://semopenalex.org/work/W2184710080> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2184710080 abstract "Biosynthetic processing of fibrillar procollagens is essential for producing mature collagen monomers that polymerize into fibrils by a self-assembly process. The metalloproteinase ADAMTS-2 is the major enzyme that processes the N-propeptide of type I procollagen in the skin and also of type II and type III procollagens. Mutations in the ADAMTS-2 gene cause dermatospraxis in animals and Ehlers-Danlos syndrome VIIC in humans, both of which are characterized by the accumulation of type I pN-collagen and the formation of abnormal collagen fibrils in the skin. Despite its importance in procollagen processing, little is known about the regulation of ADAMTS-2 expression. Here, we demonstrate that ADAMTS-2 can be regulated by 1,25-dihydroxyvitamin D3, an inducer of type I procollagen synthesis. This steroid hormone induced ADAMTS-2 mRNA ~3-fold in MG-63 human osteosarcoma cells and MC3T3-E1 murine osteoblastic cells. This induction was dose- and time-dependent in MG-63 cells. In contrast, secreted ADAMTS-2 protein was increased only 1.4-fold with 1,25-dihydroxyvitamin D3. Finally, 1,25-dihydroxyvitamin D3 in the presence of ascorbate increased levels of secreted ADAMTS-2 1.9-fold over ascorbate treatment alone, which did not appreciably change ADAMTS-2 expression. These data indicate that the regulation of ADAMTS-2 is coupled with the synthesis of type I procollagen through 1,25dihydroxyvitamin D3 signaling and may involve translational or posttranslational control." @default.
- W2184710080 created "2016-06-24" @default.
- W2184710080 creator A5049004174 @default.
- W2184710080 creator A5056954717 @default.
- W2184710080 creator A5069498782 @default.
- W2184710080 date "2006-09-01" @default.
- W2184710080 modified "2023-10-16" @default.
- W2184710080 title "Regulation of ADAMTS-2 by 1,25-Dihydroxyvitamin D3 in Osteoblastic Cells" @default.
- W2184710080 cites W1483809793 @default.
- W2184710080 cites W1514829409 @default.
- W2184710080 cites W1517312424 @default.
- W2184710080 cites W1531032256 @default.
- W2184710080 cites W1595269103 @default.
- W2184710080 cites W1595561754 @default.
- W2184710080 cites W1851592922 @default.
- W2184710080 cites W1973134563 @default.
- W2184710080 cites W1985434939 @default.
- W2184710080 cites W1986399954 @default.
- W2184710080 cites W2009869955 @default.
- W2184710080 cites W2014748951 @default.
- W2184710080 cites W2032121506 @default.
- W2184710080 cites W2039706665 @default.
- W2184710080 cites W2043324515 @default.
- W2184710080 cites W2046699020 @default.
- W2184710080 cites W2074789698 @default.
- W2184710080 cites W2081172215 @default.
- W2184710080 cites W2084285608 @default.
- W2184710080 cites W2091404907 @default.
- W2184710080 cites W2091557240 @default.
- W2184710080 cites W2113524103 @default.
- W2184710080 cites W2116169917 @default.
- W2184710080 cites W2124492445 @default.
- W2184710080 cites W2136819827 @default.
- W2184710080 cites W2156302435 @default.
- W2184710080 cites W2171778835 @default.
- W2184710080 cites W74133624 @default.
- W2184710080 hasPublicationYear "2006" @default.
- W2184710080 type Work @default.
- W2184710080 sameAs 2184710080 @default.
- W2184710080 citedByCount "0" @default.
- W2184710080 crossrefType "journal-article" @default.
- W2184710080 hasAuthorship W2184710080A5049004174 @default.
- W2184710080 hasAuthorship W2184710080A5056954717 @default.
- W2184710080 hasAuthorship W2184710080A5069498782 @default.
- W2184710080 hasConcept C109523444 @default.
- W2184710080 hasConcept C126322002 @default.
- W2184710080 hasConcept C134018914 @default.
- W2184710080 hasConcept C153911025 @default.
- W2184710080 hasConcept C167814343 @default.
- W2184710080 hasConcept C185592680 @default.
- W2184710080 hasConcept C2776224515 @default.
- W2184710080 hasConcept C2780644872 @default.
- W2184710080 hasConcept C55493867 @default.
- W2184710080 hasConcept C55728118 @default.
- W2184710080 hasConcept C64348721 @default.
- W2184710080 hasConcept C71924100 @default.
- W2184710080 hasConcept C86803240 @default.
- W2184710080 hasConceptScore W2184710080C109523444 @default.
- W2184710080 hasConceptScore W2184710080C126322002 @default.
- W2184710080 hasConceptScore W2184710080C134018914 @default.
- W2184710080 hasConceptScore W2184710080C153911025 @default.
- W2184710080 hasConceptScore W2184710080C167814343 @default.
- W2184710080 hasConceptScore W2184710080C185592680 @default.
- W2184710080 hasConceptScore W2184710080C2776224515 @default.
- W2184710080 hasConceptScore W2184710080C2780644872 @default.
- W2184710080 hasConceptScore W2184710080C55493867 @default.
- W2184710080 hasConceptScore W2184710080C55728118 @default.
- W2184710080 hasConceptScore W2184710080C64348721 @default.
- W2184710080 hasConceptScore W2184710080C71924100 @default.
- W2184710080 hasConceptScore W2184710080C86803240 @default.
- W2184710080 hasLocation W21847100801 @default.
- W2184710080 hasOpenAccess W2184710080 @default.
- W2184710080 hasPrimaryLocation W21847100801 @default.
- W2184710080 hasRelatedWork W1967810865 @default.
- W2184710080 hasRelatedWork W1968123760 @default.
- W2184710080 hasRelatedWork W1971579608 @default.
- W2184710080 hasRelatedWork W1979264581 @default.
- W2184710080 hasRelatedWork W1979388119 @default.
- W2184710080 hasRelatedWork W1985583116 @default.
- W2184710080 hasRelatedWork W1990933733 @default.
- W2184710080 hasRelatedWork W2001592564 @default.
- W2184710080 hasRelatedWork W2004730246 @default.
- W2184710080 hasRelatedWork W2046699020 @default.
- W2184710080 hasRelatedWork W2068193118 @default.
- W2184710080 hasRelatedWork W2072315707 @default.
- W2184710080 hasRelatedWork W2134391212 @default.
- W2184710080 hasRelatedWork W2152219106 @default.
- W2184710080 hasRelatedWork W2156056478 @default.
- W2184710080 hasRelatedWork W2191072416 @default.
- W2184710080 hasRelatedWork W2265756020 @default.
- W2184710080 hasRelatedWork W3100653050 @default.
- W2184710080 hasRelatedWork W3126704874 @default.
- W2184710080 hasRelatedWork W347661141 @default.
- W2184710080 isParatext "false" @default.
- W2184710080 isRetracted "false" @default.
- W2184710080 magId "2184710080" @default.
- W2184710080 workType "article" @default.