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- W2184715511 abstract "The leaves of Nauclea latifolia used in traditional medicine for the treatment of diarrhea were extracted in hot and cold ethanol with the aim of determining their antibacterial activities and toxicological potentials. Soxhlet extraction method was used for the hot ethanol extraction while for the cold ethanol ground samples were soaked in ethanol for 48h. The Agar diffusion method was used for the antibacterial assay at different concentrations on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi. Albino rats were used for toxicological studies by injecting varying doses of the extracts through the intraperitoneal route for 14 days. The growth of S. typhi was not inhibited by the extract. However the hot ethanol extract had minimum inhibitory concentrations (MICs) of 3.24mg/ml, 3.28mg/ml and 4.82mg/ml on E. coli, S aureus and P. aeruginosa respectively, while the cold ethanol extract produced MICs of 4.74mg/ml, 5.14mg/ml and 5.61 mg/ml respectively on the isolates. Hematological analyses revealed that RBC, PCV and Hb values decreased with increase in doses of extract while ESR and WBC values increased. MCHC values were lower than that obtained from the control. However, statistical analyses revealed that there were significant differences in the values obtained for RBC, PCV and Hb at the lower doses and the controls. The extracts contained alkaloids, tannins and saponins. The antibacterial assay justifies the use of the plant in palm wine preservation and possible use in preservation of other foods, and the treatment of diarrhoea. (New York Science Journal 2010;3(9):97-105). (ISSN: 1554-0200)." @default.
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- W2184715511 date "2010-01-01" @default.
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- W2184715511 title "Effect Of Crude Ethanol Extract Of Nauclea Latifolia On Some Clinical Isolates Of Food Importance And Its Toxicological Potentials" @default.
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