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- W2184754687 abstract "Respiratory mechanics and gas exchange in postobstructive pulmonary vasculopathy. S.M. Kelly, J.H.T. Bates, R.P. Michel. ERS Journals Ltd 1995. ABSTRACT: Chronic unilateral pulmonary artery ligation induces formation of new bronchial collateral vessels in the affected lung. These vessels form precapillary anastomoses with the pulmonary circulation and the lung is perfused with arterial blood. Inspired gas is diverted to the contralateral lung to maintain the ventilation/ perfusion ratio (VA/Q) and gas exchange. This study was designed to determine the mechanism responsible for this shift of ventilation, which has not previously been investigated. We studied six dogs, before and 6 months after ligation of the left main pulmonary artery. We measured pulmonary resistance (RL) and elastance (EL), minute ventilation (VE), O 2 consumption (VO 2 ) and CO 2 production (VCO 2 ) of the right and left lungs. We also examined the effect of CO 2 , atropine and isoproterenol on RL and EL. In the lung with ligated pulmonary artery: 1) VE was significantly reduced; 2) RL and EL were increased and were unresponsive to CO 2 , atropine and isoproterenol; and 3) VO 2 decreased more than VCO 2 and, consequently, respiratory quotient (RQ) was greater than 1. We conclude that, with chronic pulmonary artery obstruction, ventilation shifts to the contralateral lung because of an increase in RL and EL not related to airway smooth muscle tone." @default.
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- W2184754687 date "1995-01-01" @default.
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- W2184754687 title "Respiratory m mechanics a and g gas e exchange iin postobstructive p pulmonary v vasculopathy" @default.
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