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- W2184757061 abstract "Recently, we have found that low density lipoprotein (LDL) derived from the blood of patients with angiographically documented coronary atherosclerosis has an atherogenic potential which manifests itself in cultures of human aortic intimal cells in the accumulation of cellular lipids (mostly free and esterified cholesterol), elevation of proliferative activity and stimulation of extracellular matrix synthesis.1–6 LDL of most healthy donors were devoid of such atherogenic potential. We have established that atherogenic LDL circulating in patients blood is modified lipoprotein differing from nonatherogenic LDL of healthy donors by a low sialic acid content.7 On the other hand, rpinnyai of immunoglobulins C (IgC) fraction from the whole serum of atherosclerotic patients substantially decreased its atherogenic potential.8 We have assumed that the blood serum of atherosclerotic patients contains autoantibodies against modified (desialylated) LDL since the antibodies against LDL can stimulate the accumulation of intracellular cholesterol.9,10" @default.
- W2184757061 created "2016-06-24" @default.
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- W2184757061 date "1990-01-01" @default.
- W2184757061 modified "2023-10-18" @default.
- W2184757061 title "Antibody-Like Immunoglobulins G Against Low Density Lipoprotein that Stimulate LIPID Accumulation in Cultured Cells" @default.
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- W2184757061 doi "https://doi.org/10.1007/978-1-4684-5904-3_48" @default.
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