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- W2184760263 abstract "were studied in25patients after acutemyocardial infarction using non-invasive methods. Thedrugcaused an increase insystolic blood pressureandpulse pressure,without change indiastolic blood pressure,andaslight increase inheart rateandreduction inthepre-ejection period. Thesechanges were greater inpatients without ahistory ofleft heart failure. Itissuggested thatthis cardioselective drug possessespositive inotropic activity butonlyslight positive chronotropic activity. Thesubstance hasbeenfurther investigated asapossible antidote tounwanted cardiac side effects of thecardioselective p-blocker, metoprolol. Thechanges inthecardiovascular dynamics caused by metoprolol inpatients with acutemyocardial infarction werepromptly reversed bythis new PA-agonist. Withitspositive inotropic properties anditsefficacy inreversing theeffects ofa cardioselective p-blocker, thedrugisa potentially useful pharmacological agenttosupportan acutely depressed myocardium inpatients on p-blocking agents." @default.
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- W2184760263 date "1979-01-01" @default.
- W2184760263 modified "2023-09-26" @default.
- W2184760263 title "Haemodynamic effects ofa new p3-receptor agonist in acutemyocardial infarction A useful antidote tounwanted cardiac effects of I?- blocking agents" @default.
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