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• W2184818176 abstract "Angiogenesis plays an important role in cancer growth, and the underlying mechanisms have been studied in the search for possible therapeutic targets. As nitric oxide NO shows various physiological and pathophysiological functions in angiogenesis, numerous investigations have focused on the role of NO in tumor progression, but few such studies have investigated colorectal cancer. Interactions between NO and vascular endothelial growth factor VEGF in tumors are particularly unclear. We investigated the e#ects of NO inhibition on angiogenesis and VEGF production promoted by the COLO320DM cancer cell line implanted under mouse dorsal skin. We also investigated the e#ects of NO on relationships between tumor angiogenesis and the angiogenic factors, hepatocyte growth factor HGF and fibroblast growth factor FGF. Administration of N G -nitro-L-arginine-methyl-ester L-NAME, a NO synthase inhibitor, sig- nificantly inhibited tumor angiogenesis in this model. VEGF mRNA levels in tissue surrounding the chamber of the COLO320DM group were significantly decreased, whereas levels within the actual chamber containing tumor cells were not significantly changed. No significant changes in levels of HGF or FGF mRNA were identified. These results suggest that inhibition of angiogenesis on tissue attached to the chamber with COLO320DM may be related to decreases in mouse-derived VEGF. In addition, L-NAME may act as an anti-cancer agent through the inhibition of VEGF-induced angiogenesis." @default.
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• W2184818176 date "2005-01-01" @default.
• W2184818176 modified "2023-09-22" @default.
• W2184818176 title "L-NAME Inhibits Colon Cancer Cell-induced Angiogenesis and VEGF Production" @default.
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