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- W2184829069 abstract "The accumulation of compatible osmolytes during osmotic stress is observed in virtually all organisms. In mammals, the hypertonicity-induced expression of osmolyte transporters and synthetic enzymes is conferred by the presence of upstream tonicity-responsive enhancer (TonE) sequences. Recently, we described the cloning and initial characterization of TonE-binding protein (TonEBP), a transcription factor that translocates to the nucleus and associates with TonE sequences in a tonicity-dependent manner. We now report that hypertonicity induces an increase in TonEBP phosphorylation that temporally correlates with increased nuclear localization of the molecule. TonEBP phosphorylation is not affected by a number of kinase inhibitors, including the p38 inhibitor SB-203580. In addition, in vitro binding assays show that the association of TonEBP with TonE sequences is not affected by phosphorylation. Thus TonEBP phosphorylation is an early step in the response of cells to hypertonicity and may be required for nuclear import or retention." @default.
- W2184829069 created "2016-06-24" @default.
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- W2184829069 date "2001-02-01" @default.
- W2184829069 modified "2023-10-18" @default.
- W2184829069 title "Hypertonicity-induced phosphorylation and nuclear localization of the transcription factor TonEBP" @default.
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- W2184829069 doi "https://doi.org/10.1152/ajpcell.2001.280.2.c248" @default.
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