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• W2184838877 abstract "Seed of fenugreek, Trigonella foenum graecum (TFG) has been well investigated for its antidiabetic and antioxidative potential. In this study an attempt was made to reveal the possible synergistic effects of TFG seed extract and glibenclamide (GLB) in the regulation of diabetes mellitus and hepatic lipid peroxidation. The combined effects of TFG and GLB were compared with that of individual treatments for the regulation of alloxan induced hyperglycemia, hepatic LPO and to the changes in the status of antioxidants. High Performance Liquid Chromatography (HPLC) was also performed in order to find out the concentrations of major active compounds. Combined administration of TFG and GLB not only inhibited LPO and glucose to a great extent, but also ameliorated the alloxan induced decrease in insulin and antioxidants such as superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) as compared to the individual drugs. HPLC analyses of the test extract revealed the presence of trigonelline, quercetin and rutin; former one being in the highest proportion, suggesting its greater involvement in the TFG induced amelioration of diabetes mellitus. Our findings suggest that fenugreek seed extract, when added along with glibenclaimide may ameliorate diabetes mellitus to a greater extent as compared to monotherapy. It also greatly improved the antioxidant defense system, clearly suggesting the use of fenugreek seed extract along with glibenclamide for better diabetic control." @default.
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• W2184838877 date "2014-01-01" @default.
• W2184838877 modified "2023-09-23" @default.
• W2184838877 title "Trigonella foenum graecum Seed Extract Enhances the Antiperoxidative and Antidiabetic Activities of Glibenclamide" @default.
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