FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2184863695> ?p ?o ?g. }

• W2184863695 abstract "Hepatocellular carcinoma (HCC) is a primary malignancy of the liver. It is now the third leading cause of cancer deaths worldwide. The incidence of HCC is highest in Asia and Africa, where the endemic high prevalence of hepatitis B and hepatitis C strongly predisposes to the development of chronic liver disease and subsequent development of HCC. The present study was conducted to investigate the protective effect of cynara scolymus leaves extract against N-nitrosodiethylamine (NDEA) at a dose of 100 mg/kg b.wt and carbon tetrachloride (CCl4) at a dose of 3ml/kg b.wt -induced hepatocarcinogenesis in male Wistar albino rats. Main methods: rats were pretreated with Cynara scolymus extract, silymarin or both for six weeks prior to the injection of NDEA. Then rats administered with a single intraperitoneal injection of NDEA followed by subcutaneous injections of CCl4 once a week for 6 weeks and the pretreatment was continued for another six weeks. At the end of the experiment, blood samples were taken for biochemical analysis and liver tissues were histopathologically examined. Results of the current study showed significant increase in serum levels of AST, ALT, ALP, total and direct bilirubin and alpha fetoprotein (AFP) as well as significant decrease in albumin was observed in NDEA-intoxicated group, compared to normal control group. Pretreatment with Cynara scolymus extract, silymarin and their combination limited the increase in serum levels of AST, ALT, ALP, total and direct bilirubin and alpha fetoprotein (AFP) and produced significant increase in albumin, compared to NDEA- intoxicated group. Histopathological examination of liver of NDEA and Ccl4 treated group revealed obvious cellular damage and hepatocellular carcinoma with frequent mitotic activity and nuclear pleomorphism, meanwhile other groups pretreated with either silymarin, Cynara scolymus extract or a combination of silymarin and Cynara scolymus extract revealed improvement in the liver architecture . The current results indicated that Cynara scolymus extract possess hepatoprotective effect. (Ramadan, A., Nehal A. Afifi, Nemat Z. Yassin, Rehab F. Abdel-Rahman, Azza H. M. Hassan and Hany M. Fayed. Hepatoprotective Effect of Artichoke Extract against Pre-cancerous Lesion of Experimentally Induced Hepatocellular Carcinoma in Rats. Life Sci J 2014;11(4):43-50). (ISSN:1097-8135). http://www.lifesciencesite.com. 4" @default.
• W2184863695 created "2016-06-24" @default.
• W2184863695 creator A5000544402 @default.
• W2184863695 creator A5073479160 @default.
• W2184863695 creator A5074072600 @default.
• W2184863695 creator A5076949860 @default.
• W2184863695 date "2014-01-01" @default.
• W2184863695 modified "2023-09-27" @default.
• W2184863695 title "Hepatoprotective Effect of Artichoke Extract against Pre-cancerous Lesion of Experimentally Induced Hepatocellular Carcinoma in Rats" @default.
• W2184863695 cites W1479818030 @default.
• W2184863695 cites W1514556898 @default.
• W2184863695 cites W1597074683 @default.
• W2184863695 cites W1870790255 @default.
• W2184863695 cites W1971064287 @default.
• W2184863695 cites W1978400685 @default.
• W2184863695 cites W1983891304 @default.
• W2184863695 cites W1989604290 @default.
• W2184863695 cites W2032202007 @default.
• W2184863695 cites W2060809803 @default.
• W2184863695 cites W2063303206 @default.
• W2184863695 cites W2087710420 @default.
• W2184863695 cites W2088629624 @default.
• W2184863695 cites W2091136697 @default.
• W2184863695 cites W2094475143 @default.
• W2184863695 cites W2098801865 @default.
• W2184863695 cites W2113710155 @default.
• W2184863695 cites W2123545197 @default.
• W2184863695 cites W2129418287 @default.
• W2184863695 cites W2139025268 @default.
• W2184863695 cites W2141970258 @default.
• W2184863695 cites W2142914821 @default.
• W2184863695 cites W2143642523 @default.
• W2184863695 cites W2145209722 @default.
• W2184863695 cites W2156121176 @default.
• W2184863695 cites W2168434682 @default.
• W2184863695 cites W2181592013 @default.
• W2184863695 cites W2190495917 @default.
• W2184863695 cites W2263023695 @default.
• W2184863695 cites W80469462 @default.
• W2184863695 hasPublicationYear "2014" @default.
• W2184863695 type Work @default.
• W2184863695 sameAs 2184863695 @default.
• W2184863695 citedByCount "0" @default.
• W2184863695 crossrefType "journal-article" @default.
• W2184863695 hasAuthorship W2184863695A5000544402 @default.
• W2184863695 hasAuthorship W2184863695A5073479160 @default.
• W2184863695 hasAuthorship W2184863695A5074072600 @default.
• W2184863695 hasAuthorship W2184863695A5076949860 @default.
• W2184863695 hasConcept C102124568 @default.
• W2184863695 hasConcept C126322002 @default.
• W2184863695 hasConcept C142724271 @default.
• W2184863695 hasConcept C178790620 @default.
• W2184863695 hasConcept C185592680 @default.
• W2184863695 hasConcept C2776029263 @default.
• W2184863695 hasConcept C2776125364 @default.
• W2184863695 hasConcept C2776231280 @default.
• W2184863695 hasConcept C2776390293 @default.
• W2184863695 hasConcept C2777359374 @default.
• W2184863695 hasConcept C2777513400 @default.
• W2184863695 hasConcept C2778019345 @default.
• W2184863695 hasConcept C71924100 @default.
• W2184863695 hasConcept C90924648 @default.
• W2184863695 hasConcept C98274493 @default.
• W2184863695 hasConceptScore W2184863695C102124568 @default.
• W2184863695 hasConceptScore W2184863695C126322002 @default.
• W2184863695 hasConceptScore W2184863695C142724271 @default.
• W2184863695 hasConceptScore W2184863695C178790620 @default.
• W2184863695 hasConceptScore W2184863695C185592680 @default.
• W2184863695 hasConceptScore W2184863695C2776029263 @default.
• W2184863695 hasConceptScore W2184863695C2776125364 @default.
• W2184863695 hasConceptScore W2184863695C2776231280 @default.
• W2184863695 hasConceptScore W2184863695C2776390293 @default.
• W2184863695 hasConceptScore W2184863695C2777359374 @default.
• W2184863695 hasConceptScore W2184863695C2777513400 @default.
• W2184863695 hasConceptScore W2184863695C2778019345 @default.
• W2184863695 hasConceptScore W2184863695C71924100 @default.
• W2184863695 hasConceptScore W2184863695C90924648 @default.
• W2184863695 hasConceptScore W2184863695C98274493 @default.
• W2184863695 hasLocation W21848636951 @default.
• W2184863695 hasOpenAccess W2184863695 @default.
• W2184863695 hasPrimaryLocation W21848636951 @default.
• W2184863695 hasRelatedWork W2004110053 @default.
• W2184863695 hasRelatedWork W2011903902 @default.
• W2184863695 hasRelatedWork W2033082714 @default.
• W2184863695 hasRelatedWork W2119528205 @default.
• W2184863695 hasRelatedWork W2182107561 @default.
• W2184863695 hasRelatedWork W2184898924 @default.
• W2184863695 hasRelatedWork W2189111380 @default.
• W2184863695 hasRelatedWork W2273959916 @default.
• W2184863695 hasRelatedWork W2338943346 @default.
• W2184863695 hasRelatedWork W2374379273 @default.
• W2184863695 hasRelatedWork W2402092688 @default.
• W2184863695 hasRelatedWork W2607110932 @default.
• W2184863695 hasRelatedWork W2980506510 @default.
• W2184863695 hasRelatedWork W3113616157 @default.
• W2184863695 hasRelatedWork W3120287957 @default.
• W2184863695 hasRelatedWork W3156264697 @default.
• W2184863695 hasRelatedWork W3203376686 @default.
• W2184863695 hasRelatedWork W2109360905 @default.
• W2184863695 hasRelatedWork W2183038286 @default.

• next