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- W2184867914 abstract "antibodies, thetiter of whichwas dosedependent. A single injection stimulated theformation of antibodies. Fourinoculations induced thehighest antibody levels andthelongestpersistence ofantibody. Theadministration ofa single intradermal booster inoculation was sufficient, even inthecaseoflow-persisting antibody, toelicit a rapid increase ofantibodies tohighlevels. A primary inoculation course oftwo injections induced a sufficient antibody level which, incase ofexposure, could apparently berapidly elevated bya 0.2-ml intradermal booster inoculation. Adverse sidereactions were observed in7.of 14individuals after a 1-or 1.5-year intradermal booster inoculation. We therefore suggest thattheintramuscular andsubcutaneous routes continue tobeusedforprimary vaccinations andthat thehighly effective intradermal routeberestricted tobooster inoculations. This isthefirst longtermstudyofthis vaccine andshould bea guideline forthepreexposuretreatment ofhigh-risk personnel. Pre-exposure vaccination against rabies for high-risk personnel hasbeenrecommended for several yearsbytheWorldHealthOrganization(WHO)(11). Vaccines prepared frommammalian nervous tissues arenotsuitable dueto thehighincidence ofvaccine-derived complications after post-exposure treatment. Avianembryovaccines havenotfoundwideacceptance because theantibody response inhumansis generally low.Potent pre-exposure rabies vaccines forman havenowbeendeveloped using humandiploid cell cultures (13), andhavebeen successfully tested inanimalexperiments (8) andinhumanfield trials (1,3,4,14).The results obtained inthese studies ledustouse thistypeofvaccine inapre-exposure vaccinationstudy inourlaboratory personnel using the intradermal routeofinjection anddifferent schedules ofvaccination. Theobjectives ofthestudy weretodeternine (i) theeffectiveness ofintradermal vaccinations usinga minimalamountofvaccine, (ii) the mostefficient inoculation schedule, (iii) the persistence ofantibodies overarelatively long period oftime, and(iv) theeffect ofintradermal booster inoculations." @default.
- W2184867914 created "2016-06-24" @default.
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- W2184867914 date "1976-01-01" @default.
- W2184867914 modified "2023-09-27" @default.
- W2184867914 title "Prophylactic Immunization ofHumansAgainst Rabiesby Intradermal Inoculation ofHumanDiploid CellCulture Vaccine" @default.
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