FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2184876102> ?p ?o ?g. }

• W2184876102 abstract "Benzodiazepine potentiation of g-aminobutyric acid (GABA) neurotransmission is associated with the presence of a gamma-2 subunit in the GABAA receptor. A method was developed to modify the gamma-2 subunit expression in adult rat brain. Unilateral intracerebroventricular (i.c.v.) infusion of a 17-base phosphorothioate-modified antisense oligodeoxynucleotide (ASO) was performed every 12 hr for 3 days. Controls were treated with a sense oligodeoxynucleotide. Parasagittal brain sections were used for quantitative autoradiographic analysis of radioligand binding. ASO treatment caused a 15% to 25% decrease of specific [ 3 H]flunitrazepam binding in most brain areas, with statistically significant decreases in frontal cortex, cerebellar molecular layer, zona reticulata of substantia nigra and CA3 of hippocampus. In contrast, [ 3 H]muscimol binding was not changed. [ 3 H]GABA binding was also unchanged, except for a 10% decrease in cerebellar granule cell layer. The effect on the chloride channel of the GABAA receptor complex was examined by 49ethynyl-4-n-[2,3- 3 H2]propylbicycloorthobenzoate binding; most brain areas showed small decreases in 49-ethynyl-4-n-[2,33 H2]propylbicycloorthobenzoate binding. However, hippocampal regions showed much larger decreases. Binding of the adenosine A1 receptor antagonist [ 3 H]8-cyclopentyl-1,3-dipropylxanthine was used to examine possible secondary effects of the ASO. There was a decrease in [ 3 H]8-cyclopentyl-1,3-dipropylxanthine binding, but this was much smaller than the change in [ 3 H]flunitrazepam binding, and no area showed a significant effect. Quantitative immunoblotting with a monoclonal antibody that recognizes GABAA receptor beta-2 and beta-3 subunits showed no change in immunoreactivity in cerebellar tissue after ASO treatment. The results indicate a selective effect on benzodiazepine binding to GABAA receptors and a possible change in receptor subunit composition." @default.
• W2184876102 created "2016-06-24" @default.
• W2184876102 creator A5007641079 @default.
• W2184876102 creator A5045289644 @default.
• W2184876102 creator A5073704204 @default.
• W2184876102 creator A5077245587 @default.
• W2184876102 date "1998-01-01" @default.
• W2184876102 modified "2023-09-27" @default.
• W2184876102 title "Decreased Benzodiazepine Binding with Little Effect on g-Aminobutyric Acid Binding in Rat Brain After Treatment with Antisense Oligodeoxynucleotide to the g-Aminobutyric" @default.
• W2184876102 cites W1508300860 @default.
• W2184876102 cites W1517091349 @default.
• W2184876102 cites W1524203275 @default.
• W2184876102 cites W1538927534 @default.
• W2184876102 cites W1563564990 @default.
• W2184876102 cites W1647312149 @default.
• W2184876102 cites W1905429706 @default.
• W2184876102 cites W1929455229 @default.
• W2184876102 cites W1967878409 @default.
• W2184876102 cites W1980916054 @default.
• W2184876102 cites W1981952784 @default.
• W2184876102 cites W1983967908 @default.
• W2184876102 cites W1990067519 @default.
• W2184876102 cites W1994261508 @default.
• W2184876102 cites W2014957268 @default.
• W2184876102 cites W2016763640 @default.
• W2184876102 cites W2025810192 @default.
• W2184876102 cites W2032218383 @default.
• W2184876102 cites W2034341968 @default.
• W2184876102 cites W2042976056 @default.
• W2184876102 cites W2053256744 @default.
• W2184876102 cites W2059864318 @default.
• W2184876102 cites W2060139211 @default.
• W2184876102 cites W2067862458 @default.
• W2184876102 cites W2079775510 @default.
• W2184876102 cites W2081198173 @default.
• W2184876102 cites W2081218281 @default.
• W2184876102 cites W2085783013 @default.
• W2184876102 cites W2106915249 @default.
• W2184876102 cites W2124614145 @default.
• W2184876102 cites W2133458388 @default.
• W2184876102 cites W2163815564 @default.
• W2184876102 cites W2176076159 @default.
• W2184876102 cites W2295460480 @default.
• W2184876102 cites W2330700346 @default.
• W2184876102 cites W2417914351 @default.
• W2184876102 cites W64568169 @default.
• W2184876102 cites W2624701741 @default.
• W2184876102 hasPublicationYear "1998" @default.
• W2184876102 type Work @default.
• W2184876102 sameAs 2184876102 @default.
• W2184876102 citedByCount "0" @default.
• W2184876102 crossrefType "journal-article" @default.
• W2184876102 hasAuthorship W2184876102A5007641079 @default.
• W2184876102 hasAuthorship W2184876102A5045289644 @default.
• W2184876102 hasAuthorship W2184876102A5073704204 @default.
• W2184876102 hasAuthorship W2184876102A5077245587 @default.
• W2184876102 hasConcept C126322002 @default.
• W2184876102 hasConcept C134018914 @default.
• W2184876102 hasConcept C148762608 @default.
• W2184876102 hasConcept C168258287 @default.
• W2184876102 hasConcept C170493617 @default.
• W2184876102 hasConcept C185592680 @default.
• W2184876102 hasConcept C2777123777 @default.
• W2184876102 hasConcept C2779188335 @default.
• W2184876102 hasConcept C2781210498 @default.
• W2184876102 hasConcept C2781442855 @default.
• W2184876102 hasConcept C55493867 @default.
• W2184876102 hasConcept C67847695 @default.
• W2184876102 hasConcept C71924100 @default.
• W2184876102 hasConcept C86803240 @default.
• W2184876102 hasConcept C98274493 @default.
• W2184876102 hasConceptScore W2184876102C126322002 @default.
• W2184876102 hasConceptScore W2184876102C134018914 @default.
• W2184876102 hasConceptScore W2184876102C148762608 @default.
• W2184876102 hasConceptScore W2184876102C168258287 @default.
• W2184876102 hasConceptScore W2184876102C170493617 @default.
• W2184876102 hasConceptScore W2184876102C185592680 @default.
• W2184876102 hasConceptScore W2184876102C2777123777 @default.
• W2184876102 hasConceptScore W2184876102C2779188335 @default.
• W2184876102 hasConceptScore W2184876102C2781210498 @default.
• W2184876102 hasConceptScore W2184876102C2781442855 @default.
• W2184876102 hasConceptScore W2184876102C55493867 @default.
• W2184876102 hasConceptScore W2184876102C67847695 @default.
• W2184876102 hasConceptScore W2184876102C71924100 @default.
• W2184876102 hasConceptScore W2184876102C86803240 @default.
• W2184876102 hasConceptScore W2184876102C98274493 @default.
• W2184876102 hasLocation W21848761021 @default.
• W2184876102 hasOpenAccess W2184876102 @default.
• W2184876102 hasPrimaryLocation W21848761021 @default.
• W2184876102 hasRelatedWork W1902334961 @default.
• W2184876102 hasRelatedWork W1980111787 @default.
• W2184876102 hasRelatedWork W1987753347 @default.
• W2184876102 hasRelatedWork W1991371290 @default.
• W2184876102 hasRelatedWork W2002741384 @default.
• W2184876102 hasRelatedWork W2019261402 @default.
• W2184876102 hasRelatedWork W2019301452 @default.
• W2184876102 hasRelatedWork W2019923712 @default.
• W2184876102 hasRelatedWork W2032787214 @default.
• W2184876102 hasRelatedWork W2035710317 @default.
• W2184876102 hasRelatedWork W2044702390 @default.

• next