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- W2184878662 abstract "Objective: Luteinizing hormone (LH) requirement in assisted reproductive treatment (ART) cycles is still controversial. The objective of this study was to investigate the impact of providing LH activity with recombinant LH (rLH) on the oocyte and embryo quality in both GnRH agonist long and antagonist ART cycles of normoresponder women <40 years. Materials and Methods: A retrospective cohort study of 351 normoresponder IVF patients <40 years was carried out. Agonist long protocol was performed in 184 women and the antagonist in 167. Stimulation was performed in both protocols with either recombinant follicle stimulating hormone (rFSH) alone or rFSH plus rLH. Cycle characteristics and outcomes, primarily the proportions of mature oocytes and good-quality embryos were evaluated according to rLH addition in the two most commonly used stimulation protocols. Results: In the agonist long protocol, a significantly higher number of total oocytes (17.6±5.8 vs 15±6.8; p=0.005) and a significantly higher rate of mature oocytes (75% vs 70%; p=0.02) were obtained, although embryo quality was similar in rFSH alone cycles compared to the rLH supplemented ones. In the antagonist protocol, significantly more oocytes were retrieved in the rFSH alone group (16.3±7.5 vs 12.8±5.1; p=0.001), although this was not reflected to oocyte maturation and embryo development. Fertilization, implantation, clinical pregnancy, miscarriage and ongoing pregnancy rates did not differ when rLH was included in both protocols. Discussion: Recombinant LH supplementation in agonist long ART cycles was found to have a detrimental effect on the oocyte quality, without a beneficial or adverse effect on the embryo quality in normoresponder women <40 years. Inclusion of rLH during stimulation in antagonist ART cycles, on the other hand, is neither favourable nor deleterious for the oocyte or the embryo quality in normoresponder women <40 years." @default.
- W2184878662 created "2016-06-24" @default.
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- W2184878662 date "2008-01-01" @default.
- W2184878662 modified "2023-09-27" @default.
- W2184878662 title "Effect of Combining Recombinant FSH with Recombinant LH on Oocyte and Embryo Quality in the GnRH Agonist Long and Antagonist Cycles" @default.
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