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• W2184879844 abstract "SUMMARY The synaptic insertion or removal of AMPA receptors (AMPAR) plays critical roles in the regulation of synaptic activity reflected in the expression of long-term potentiation (LTP) and long-term depression (LTD). The cellular events underlying this important process in learning and memory are still being revealed. Here we describe and characterize the AAA + ATPase Thorase, which regulates the expression of surface AMPAR. In an ATPase-dependent manner Thorase mediates the internalization of AMPAR by disassembling the AMPAR-GRIP1 complex. Following genetic deletion of Thorase, the internalization of AMPAR is substantially reduced, leading to increased amplitudes of miniature excitatory postsynaptic currents, enhancement of LTP, and elimination of LTD. These molecular events are expressed as deficits in learning and memory in Thorase null mice. This study identifies an AAA + ATPase that plays a critical role in" @default.
• W2184879844 created "2016-06-24" @default.
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• W2184879844 date "2011-01-01" @default.
• W2184879844 modified "2023-09-26" @default.
• W2184879844 title "The AAA + ATPase Thorase Regulates" @default.
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• W2184879844 hasPublicationYear "2011" @default.
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