Matches in SemOpenAlex for { <https://semopenalex.org/work/W2184881651> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2184881651 abstract "The antitumor activity of a new highly water-soluble platinum derivative, (1,2-diaminocyclohexaneXisocitrato)platinum(ll) (NSC 350602; PHIC), was studied in 11210 leukemia cells inoculated into mice. PHIC was found to be active for i.p. graft-i.p. treatment, i.p. graft-i.v. treatment, and i.v. graft-p.o. treatment. A significant activity was observed on early and advanced L1210 leukemia even when the treatment was delayed 6 days after the graft. A comparison between the activities of PHIC, cisplatin (NSC 119875), and (4-carboxyphthalatoX1,2-diaminocyclohexane)platinum(ll) (NSC 271674; DACCP) for i.p. graft-i.p. treatment indicated that the highest activity was observed for divided doses rather than single dose in the case of PHIC and DACCP and not for cisplatin. Under these conditions, PHIC gave larger treated versus control survival time values or a greater number of surviving animals than did cisplatin and DACCP. No crossresistance between PHIC and cisplatin could be detected in L1210 leukemia cells resistant to cisplatin. Mutagenicity studies on Salmonella typhimurium revealed that PHIC is far less mutagenie than cisplatin on TA100 and TA98 strains. Other pharma cological parameters, such as growth inhibition rate of cultured L1210 cells, penetration, and DNA binding in L1210 cells inocu lated in mice, were compared for PHIC and cisplatin together with their in vitro rates of hydrolysis and platinum:DNA adducts. No nephrotoxicity was detected with PHIC at the maximum nonlethal dose level in mice in contrast to results with cisplatin. A preclinical study was conducted in baboons at 100,150, and 200 mg/kg. No nephrotoxicity could be detected at a dose of 100 mg/kg without prehydration for six courses at 3-week intervals. At 200 mg/kg, an increase of blood creatinine was controlled by prehydration. Gastrointestinal toxicity was mild during the three regimens. Phase I clinical trials are under way." @default.
- W2184881651 created "2016-06-24" @default.
- W2184881651 creator A5031136186 @default.
- W2184881651 creator A5035004993 @default.
- W2184881651 creator A5082689339 @default.
- W2184881651 date "1984-01-01" @default.
- W2184881651 modified "2023-09-27" @default.
- W2184881651 title "Diaminocyclohexane(isocitrato)platinum(ll)1" @default.
- W2184881651 cites W1481126405 @default.
- W2184881651 cites W1581672612 @default.
- W2184881651 cites W1608729055 @default.
- W2184881651 cites W1851015666 @default.
- W2184881651 cites W2058231848 @default.
- W2184881651 cites W2062576625 @default.
- W2184881651 cites W20631262 @default.
- W2184881651 cites W2065587732 @default.
- W2184881651 cites W2078158666 @default.
- W2184881651 cites W2081801819 @default.
- W2184881651 cites W2138717514 @default.
- W2184881651 cites W2152601635 @default.
- W2184881651 cites W2237040806 @default.
- W2184881651 cites W2337857018 @default.
- W2184881651 cites W2410720557 @default.
- W2184881651 cites W2416022751 @default.
- W2184881651 cites W29794782 @default.
- W2184881651 cites W31750938 @default.
- W2184881651 hasPublicationYear "1984" @default.
- W2184881651 type Work @default.
- W2184881651 sameAs 2184881651 @default.
- W2184881651 citedByCount "0" @default.
- W2184881651 crossrefType "journal-article" @default.
- W2184881651 hasAuthorship W2184881651A5031136186 @default.
- W2184881651 hasAuthorship W2184881651A5035004993 @default.
- W2184881651 hasAuthorship W2184881651A5082689339 @default.
- W2184881651 hasConcept C109316439 @default.
- W2184881651 hasConcept C126189478 @default.
- W2184881651 hasConcept C126322002 @default.
- W2184881651 hasConcept C161790260 @default.
- W2184881651 hasConcept C178790620 @default.
- W2184881651 hasConcept C185592680 @default.
- W2184881651 hasConcept C202751555 @default.
- W2184881651 hasConcept C207001950 @default.
- W2184881651 hasConcept C2776694085 @default.
- W2184881651 hasConcept C2778239845 @default.
- W2184881651 hasConcept C2780017796 @default.
- W2184881651 hasConcept C29730261 @default.
- W2184881651 hasConcept C518104683 @default.
- W2184881651 hasConcept C54355233 @default.
- W2184881651 hasConcept C55493867 @default.
- W2184881651 hasConcept C71924100 @default.
- W2184881651 hasConcept C86803240 @default.
- W2184881651 hasConcept C98274493 @default.
- W2184881651 hasConceptScore W2184881651C109316439 @default.
- W2184881651 hasConceptScore W2184881651C126189478 @default.
- W2184881651 hasConceptScore W2184881651C126322002 @default.
- W2184881651 hasConceptScore W2184881651C161790260 @default.
- W2184881651 hasConceptScore W2184881651C178790620 @default.
- W2184881651 hasConceptScore W2184881651C185592680 @default.
- W2184881651 hasConceptScore W2184881651C202751555 @default.
- W2184881651 hasConceptScore W2184881651C207001950 @default.
- W2184881651 hasConceptScore W2184881651C2776694085 @default.
- W2184881651 hasConceptScore W2184881651C2778239845 @default.
- W2184881651 hasConceptScore W2184881651C2780017796 @default.
- W2184881651 hasConceptScore W2184881651C29730261 @default.
- W2184881651 hasConceptScore W2184881651C518104683 @default.
- W2184881651 hasConceptScore W2184881651C54355233 @default.
- W2184881651 hasConceptScore W2184881651C55493867 @default.
- W2184881651 hasConceptScore W2184881651C71924100 @default.
- W2184881651 hasConceptScore W2184881651C86803240 @default.
- W2184881651 hasConceptScore W2184881651C98274493 @default.
- W2184881651 hasLocation W21848816511 @default.
- W2184881651 hasOpenAccess W2184881651 @default.
- W2184881651 hasPrimaryLocation W21848816511 @default.
- W2184881651 hasRelatedWork W1525583476 @default.
- W2184881651 hasRelatedWork W1873699188 @default.
- W2184881651 hasRelatedWork W1982341459 @default.
- W2184881651 hasRelatedWork W2018000748 @default.
- W2184881651 hasRelatedWork W2025046865 @default.
- W2184881651 hasRelatedWork W2030815676 @default.
- W2184881651 hasRelatedWork W2067022076 @default.
- W2184881651 hasRelatedWork W2067503361 @default.
- W2184881651 hasRelatedWork W2240005626 @default.
- W2184881651 hasRelatedWork W2315980461 @default.
- W2184881651 hasRelatedWork W2358562771 @default.
- W2184881651 hasRelatedWork W2363003443 @default.
- W2184881651 hasRelatedWork W2369764254 @default.
- W2184881651 hasRelatedWork W2398844858 @default.
- W2184881651 hasRelatedWork W2398845841 @default.
- W2184881651 hasRelatedWork W2545657964 @default.
- W2184881651 hasRelatedWork W2559882666 @default.
- W2184881651 hasRelatedWork W3028669832 @default.
- W2184881651 hasRelatedWork W3089030382 @default.
- W2184881651 hasRelatedWork W589398449 @default.
- W2184881651 isParatext "false" @default.
- W2184881651 isRetracted "false" @default.
- W2184881651 magId "2184881651" @default.
- W2184881651 workType "article" @default.