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• W2184897479 abstract "The serotonin transporter (5-HTT) as a key regulator of central serotonergic activity has been linked to neuropsychiatric disorders like anxiety and depression. The evidence of a connection between such mood disorders and genetic variations of the Serotonin transporter led to the generation of 5-HTT knockout mice with a targeted inactivation of the 5-HTT function. These mice, contingent upon their genotypes, differentially express functional 5-HTT. Homozygous knockouts completely lack the 5-HTT, heterozygous mice show a reduced 5-HTT density of about 50%, while wild-type controls express normal levels of 5-HTT. Behavioral phenotyping revealed that 5-HTT knockout mice display a number of phenotypic changes especially regarding anxiety related behavior. On the one hand it is known that 5-HTT as well as 5-HT receptor subtypes are abundant in the cortical areas involved in cognitive functions, implying also an important role in learning and memory. On the other hand, cognitive processes are well known to be strongly influenced by emotionality, possibly modulated by stress-related adrenal steroid hormones. In the present study we evaluated whether spatial memory is affected by the genotype per se or if there is an interference of differences in the aversiveness of the testing conditions. We therefore conducted different learning and memory tasks in order to measure how the performance is affected by the 5-HTT genotype and differences in the aversiveness of testing conditions. Methods Male 5-HTT knockout mice (n=28), heterozygous 5-HTT mice (n=28), and wild-type controls (n=28) have been subjected to a 5 day series of repeated trials in either a water maze or a Barnes maze. An additional group of male mice of all three genotypes (KO n=32, HET n=36, WT n=30) were used to measure how the different testing procedures are related to plasma corticosterone concentrations, the main stress hormone of the murine hypothalamic-pituitary-adreno-cortical axis. These mice were sacrificed 15 minutes after a single session of the respective tests or, as a control, without any test experience. The water maze apparatus consisted of a circular pool (1 m in diameter) made of blue plastic. The pool was filled with water (21 °C) to a height of 33 cm. An escape platform made of transparent plastic was submerged 0.5 cm under the water surface. Three-dimensional visual cues were placed around the water maze. We measure the time until the mice found the submerged platform by means of an automated tracking system (http://www.phenotyping.de/digital.html). The test was conducted on four consecutive days with three trials per day using the same platform position. On the fifth day a different position had to be found. The Barnes maze apparatus consisted of a round white platform (1 m in diameter) that was elevated 127 cm above the floor. The platform was surrounded by three-dimensional visual cues. From the platform the mice could escape to their home cage (placed directly beneath the table, not visible for the mice) via one of 12 holes (3 cm diameter) at the border of the platform. The escape hole was connected to the home cage by a wire-mesh tunnel. The other holes led to little blind-ending mesh tunnels. We measured the time to find the correct hole that leads back to the home cage of the mouse by means of an automated tracking system (see above). The test was conducted on four consecutive days with two trials per day using the same escape hole. On the fifth day a different escape hole had to be found." @default.
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• W2184897479 date "2012-01-01" @default.
• W2184897479 modified "2023-09-22" @default.
• W2184897479 title "Different Spatial Learning Performance of 5-Htt Knockout Mice on Land or Water" @default.
• W2184897479 hasPublicationYear "2012" @default.
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