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- W2184959068 abstract "Summary A variety of 1-substituted imidazoles (1a-1d, 2a-2d) were synthesized and characterised by FTIR, 1 HNMR, DART-MS and Elemental spectral data. Synthesized compounds were screened for their antiulcer activity by Indomethacin with pylorus ligation induced ulcer and absolute alcohol induced ulcer model. Parameters like gastric volume, pH, free acidity, total acidity, ulcer index and % inhibition were measured for antiulcer activity at 20 and 40 mg/kg and compared with the standard drug Ranitidine at 20mg/kg. Histopathological studies of stomachs were performed for all groups and interpreted. The ulcer index in the test group was found to be significantly less (P<0.01) when compared to control group and comparable with that of standard. At higher dose (40 mg/kg) of both the model, compounds 1b and 2b reduced these ulcer lesions as evidenced by a significant (P < 0.01) reduction in the ulcer index when compared with the control group." @default.
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- W2184959068 date "2010-01-01" @default.
- W2184959068 modified "2023-09-27" @default.
- W2184959068 title "ANTI-ULCER ACTIVITY OF 1-SUBSTITUTED IMIDAZOLES AGAINST GASTRIC ULCERS IN RATS" @default.
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