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- W2184959405 abstract "somatostatin analogue, octreotide, restores normalpressure profiles indis- ordersofuppergutmotility. Thisstudy aimedtoevaluate theacuteeffects of octreotide infivehealthy subjects andin 50consecutive patients withfunctional (n=22)or organic(n=28)dysmotility. Antroduodenojejunal manometry was performed duringthreehours'fasting, fortwohoursafter astandard meal,and 30minutes after subcutaneous injection of 50,ugoctreotide. Antralmotility, before andafter octreotide, andcharacteristics ofspontaneous migrating motor com- plexesand octreotide inducedactivity fronts werecompared. Octreotide inhib- itedantral motility andinduced a small intestinal activity frontfollowed bymotor quiescence inallhealthy subjects and patients. Theduration andpropagation velocity ofactivity fronts were greater thanthoseof spontaneousmigrating motor complexes. Thirtyper centof activity frontsbegansimultaneously at different levels ofsmallbowel, andin20%/ a second, normally propagated activity frontdeveloped within30 minutesof octreotide injection. Octreotide induces rapidly propagated, longactivity fronts, evenin patients withneuropathology, and thismay initially facilitate the intestinalpropulsionof chyme. Propulsion may notoccur,however, if octreotide induces simultaneous activity fronts oriftheactivity front isfollowed by prolonged quiescence. Inhibition ofantral motility suggests thatoctreotide may not beeffective ingastroparesis. (Gut1994; 35:1064-1069)" @default.
- W2184959405 created "2016-06-24" @default.
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- W2184959405 date "1994-01-01" @default.
- W2184959405 modified "2023-09-27" @default.
- W2184959405 title "Effect ofoctreotide ongastrointestinal pressure profiles inhealth andinfunctional andorganic gastrointestinal disorders" @default.
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