Matches in SemOpenAlex for { <https://semopenalex.org/work/W2184966207> ?p ?o ?g. }
- W2184966207 endingPage "878" @default.
- W2184966207 startingPage "868" @default.
- W2184966207 abstract "This study tested the hypothesis that encapsulation of influenza vaccine in microneedle patches increases vaccine stability during storage at elevated temperature.Whole inactivated influenza virus vaccine (A/Puerto Rico/8/34) was formulated into dissolving microneedle patches and vaccine stability was evaluated by in vitro and in vivo assays of antigenicity and immunogenicity after storage for up to 3 months at 4, 25, 37 and 45°C.While liquid vaccine completely lost potency as determined by hemagglutination (HA) activity within 1-2 weeks outside of refrigeration, vaccine in microneedle patches lost 40-50% HA activity during or shortly after fabrication, but then had no significant additional loss of activity over 3 months of storage, independent of temperature. This level of stability required reduced humidity by packaging with desiccant, but was not affected by presence of oxygen. This finding was consistent with additional stability assays, including antigenicity of the vaccine measured by ELISA, virus particle morphological structure captured by transmission electron microscopy and protective immune responses by immunization of mice in vivo.These data show that inactivated influenza vaccine encapsulated in dissolving microneedle patches has enhanced stability during extended storage at elevated temperatures." @default.
- W2184966207 created "2016-06-24" @default.
- W2184966207 creator A5003344100 @default.
- W2184966207 creator A5021227129 @default.
- W2184966207 creator A5023185995 @default.
- W2184966207 creator A5029077264 @default.
- W2184966207 creator A5030894404 @default.
- W2184966207 creator A5073209496 @default.
- W2184966207 date "2015-12-01" @default.
- W2184966207 modified "2023-10-16" @default.
- W2184966207 title "Enhanced Stability of Inactivated Influenza Vaccine Encapsulated in Dissolving Microneedle Patches" @default.
- W2184966207 cites W1491551588 @default.
- W2184966207 cites W184277776 @default.
- W2184966207 cites W1964509585 @default.
- W2184966207 cites W1968929160 @default.
- W2184966207 cites W1971863415 @default.
- W2184966207 cites W1985117052 @default.
- W2184966207 cites W1989284314 @default.
- W2184966207 cites W1991535548 @default.
- W2184966207 cites W1992825921 @default.
- W2184966207 cites W1997895087 @default.
- W2184966207 cites W1998361394 @default.
- W2184966207 cites W2003867438 @default.
- W2184966207 cites W2007539416 @default.
- W2184966207 cites W2011736607 @default.
- W2184966207 cites W2013315584 @default.
- W2184966207 cites W2036937828 @default.
- W2184966207 cites W2044626335 @default.
- W2184966207 cites W2047768913 @default.
- W2184966207 cites W2053546720 @default.
- W2184966207 cites W2054469972 @default.
- W2184966207 cites W2058460104 @default.
- W2184966207 cites W2065091884 @default.
- W2184966207 cites W2069746455 @default.
- W2184966207 cites W2072531995 @default.
- W2184966207 cites W2082700446 @default.
- W2184966207 cites W2088368520 @default.
- W2184966207 cites W2089143024 @default.
- W2184966207 cites W2095925146 @default.
- W2184966207 cites W2103742770 @default.
- W2184966207 cites W2114347909 @default.
- W2184966207 cites W2116085039 @default.
- W2184966207 cites W2118575072 @default.
- W2184966207 cites W2126991211 @default.
- W2184966207 cites W2127736441 @default.
- W2184966207 cites W2138469833 @default.
- W2184966207 cites W216000200 @default.
- W2184966207 cites W2161001526 @default.
- W2184966207 cites W2166851592 @default.
- W2184966207 cites W972255519 @default.
- W2184966207 doi "https://doi.org/10.1007/s11095-015-1833-9" @default.
- W2184966207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4777640" @default.
- W2184966207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26620313" @default.
- W2184966207 hasPublicationYear "2015" @default.
- W2184966207 type Work @default.
- W2184966207 sameAs 2184966207 @default.
- W2184966207 citedByCount "61" @default.
- W2184966207 countsByYear W21849662072016 @default.
- W2184966207 countsByYear W21849662072017 @default.
- W2184966207 countsByYear W21849662072018 @default.
- W2184966207 countsByYear W21849662072019 @default.
- W2184966207 countsByYear W21849662072020 @default.
- W2184966207 countsByYear W21849662072021 @default.
- W2184966207 countsByYear W21849662072022 @default.
- W2184966207 countsByYear W21849662072023 @default.
- W2184966207 crossrefType "journal-article" @default.
- W2184966207 hasAuthorship W2184966207A5003344100 @default.
- W2184966207 hasAuthorship W2184966207A5021227129 @default.
- W2184966207 hasAuthorship W2184966207A5023185995 @default.
- W2184966207 hasAuthorship W2184966207A5029077264 @default.
- W2184966207 hasAuthorship W2184966207A5030894404 @default.
- W2184966207 hasAuthorship W2184966207A5073209496 @default.
- W2184966207 hasBestOaLocation W21849662072 @default.
- W2184966207 hasConcept C147483822 @default.
- W2184966207 hasConcept C150903083 @default.
- W2184966207 hasConcept C159047783 @default.
- W2184966207 hasConcept C185592680 @default.
- W2184966207 hasConcept C203014093 @default.
- W2184966207 hasConcept C207001950 @default.
- W2184966207 hasConcept C22070199 @default.
- W2184966207 hasConcept C2522874641 @default.
- W2184966207 hasConcept C2779026604 @default.
- W2184966207 hasConcept C2780441014 @default.
- W2184966207 hasConcept C2780689484 @default.
- W2184966207 hasConcept C2780868878 @default.
- W2184966207 hasConcept C86803240 @default.
- W2184966207 hasConcept C8891405 @default.
- W2184966207 hasConcept C89423630 @default.
- W2184966207 hasConceptScore W2184966207C147483822 @default.
- W2184966207 hasConceptScore W2184966207C150903083 @default.
- W2184966207 hasConceptScore W2184966207C159047783 @default.
- W2184966207 hasConceptScore W2184966207C185592680 @default.
- W2184966207 hasConceptScore W2184966207C203014093 @default.
- W2184966207 hasConceptScore W2184966207C207001950 @default.
- W2184966207 hasConceptScore W2184966207C22070199 @default.
- W2184966207 hasConceptScore W2184966207C2522874641 @default.
- W2184966207 hasConceptScore W2184966207C2779026604 @default.
- W2184966207 hasConceptScore W2184966207C2780441014 @default.