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- W2184968107 abstract "The main objective of this work was to formulation development of the Aspirin delayed release tablets and to understand the kinetics of drug release by applying mathematical and model-dependent approaches. Six formulations of delayed release tablets were prepared by the direct compression method and simple pan coating using Drug coat N-100 and Hydroxypropylmethylcellulose phthalate (HPMCP) as enteric coating polymers. The in vitro drug release was studied in pH 1.2 HCl and 6.8pH phosphate buffer using USP dissolution Apparatus 2 at 100 rpm. Zero-order, first-order, Higuchi, and Korsmeyer et al. models were used to estimate the kinetics of drug release. The criteria for selecting the most appropriate model were based on the goodness-of-fit test and lowest sum of squares residual. Drug release from the optimal batch was explained by the Higuchi model. The difference in percent cumulative drug release of each point was highest for the optimum batch." @default.
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- W2184968107 date "2011-01-01" @default.
- W2184968107 modified "2023-09-27" @default.
- W2184968107 title "FORMULATION DEVELOPMENT AND EVALUATION OF ASPIRIN DELAYED RELEASE TABLETS Research Article" @default.
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