Matches in SemOpenAlex for { <https://semopenalex.org/work/W2185014763> ?p ?o ?g. }
- W2185014763 abstract "Hepatic insulin resistance and nonalcoholic steatohepatitis (NASH) could be caused by excessive hepatic lipid accumulation and peroxidation. Vitamin E has become a standard treatment for NASH. However, astaxanthin, an antioxidant carotenoid, inhibits lipid peroxidation more potently than vitamin E. Here, we compared the effects of astaxanthin and vitamin E in NASH. We first demonstrated that astaxanthin ameliorated hepatic steatosis in both genetically (ob/ob) and high-fat-diet-induced obese mice. In a lipotoxic model of NASH: mice fed a high-cholesterol and high-fat diet, astaxanthin alleviated excessive hepatic lipid accumulation and peroxidation, increased the proportion of M1-type macrophages/Kupffer cells, and activated stellate cells to improve hepatic inflammation and fibrosis. Moreover, astaxanthin caused an M2-dominant shift in macrophages/Kupffer cells and a subsequent reduction in CD4(+) and CD8(+) T cell recruitment in the liver, which contributed to improved insulin resistance and hepatic inflammation. Importantly, astaxanthin reversed insulin resistance, as well as hepatic inflammation and fibrosis, in pre-existing NASH. Overall, astaxanthin was more effective at both preventing and treating NASH compared with vitamin E in mice. Furthermore, astaxanthin improved hepatic steatosis and tended to ameliorate the progression of NASH in biopsy-proven human subjects. These results suggest that astaxanthin might be a novel and promising treatment for NASH." @default.
- W2185014763 created "2016-06-24" @default.
- W2185014763 creator A5000046645 @default.
- W2185014763 creator A5008003570 @default.
- W2185014763 creator A5008663654 @default.
- W2185014763 creator A5055368292 @default.
- W2185014763 creator A5069065380 @default.
- W2185014763 creator A5072175595 @default.
- W2185014763 creator A5072760293 @default.
- W2185014763 creator A5085416114 @default.
- W2185014763 date "2015-11-25" @default.
- W2185014763 modified "2023-10-15" @default.
- W2185014763 title "Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E" @default.
- W2185014763 cites W1565527343 @default.
- W2185014763 cites W1574441056 @default.
- W2185014763 cites W1963683487 @default.
- W2185014763 cites W1969190545 @default.
- W2185014763 cites W1980376777 @default.
- W2185014763 cites W1985333297 @default.
- W2185014763 cites W1995182797 @default.
- W2185014763 cites W1996869377 @default.
- W2185014763 cites W2010330364 @default.
- W2185014763 cites W2010698039 @default.
- W2185014763 cites W2022251072 @default.
- W2185014763 cites W2024138646 @default.
- W2185014763 cites W2025064703 @default.
- W2185014763 cites W2025591894 @default.
- W2185014763 cites W2031434506 @default.
- W2185014763 cites W2032069060 @default.
- W2185014763 cites W2032256472 @default.
- W2185014763 cites W2043669094 @default.
- W2185014763 cites W2047257800 @default.
- W2185014763 cites W2062812115 @default.
- W2185014763 cites W2067740038 @default.
- W2185014763 cites W2074203821 @default.
- W2185014763 cites W2077569421 @default.
- W2185014763 cites W2080755877 @default.
- W2185014763 cites W2094884053 @default.
- W2185014763 cites W2104551096 @default.
- W2185014763 cites W2106768039 @default.
- W2185014763 cites W2107683043 @default.
- W2185014763 cites W2119305519 @default.
- W2185014763 cites W2120805022 @default.
- W2185014763 cites W2124664603 @default.
- W2185014763 cites W2134668199 @default.
- W2185014763 cites W2135737717 @default.
- W2185014763 cites W2138915349 @default.
- W2185014763 cites W2145697808 @default.
- W2185014763 cites W2146299636 @default.
- W2185014763 cites W2158686289 @default.
- W2185014763 cites W2160573509 @default.
- W2185014763 cites W2163837559 @default.
- W2185014763 cites W2164118055 @default.
- W2185014763 cites W2165802855 @default.
- W2185014763 cites W2165803417 @default.
- W2185014763 cites W2170429938 @default.
- W2185014763 cites W2409752663 @default.
- W2185014763 cites W4242162525 @default.
- W2185014763 doi "https://doi.org/10.1038/srep17192" @default.
- W2185014763 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4658633" @default.
- W2185014763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26603489" @default.
- W2185014763 hasPublicationYear "2015" @default.
- W2185014763 type Work @default.
- W2185014763 sameAs 2185014763 @default.
- W2185014763 citedByCount "172" @default.
- W2185014763 countsByYear W21850147632016 @default.
- W2185014763 countsByYear W21850147632017 @default.
- W2185014763 countsByYear W21850147632018 @default.
- W2185014763 countsByYear W21850147632019 @default.
- W2185014763 countsByYear W21850147632020 @default.
- W2185014763 countsByYear W21850147632021 @default.
- W2185014763 countsByYear W21850147632022 @default.
- W2185014763 countsByYear W21850147632023 @default.
- W2185014763 crossrefType "journal-article" @default.
- W2185014763 hasAuthorship W2185014763A5000046645 @default.
- W2185014763 hasAuthorship W2185014763A5008003570 @default.
- W2185014763 hasAuthorship W2185014763A5008663654 @default.
- W2185014763 hasAuthorship W2185014763A5055368292 @default.
- W2185014763 hasAuthorship W2185014763A5069065380 @default.
- W2185014763 hasAuthorship W2185014763A5072175595 @default.
- W2185014763 hasAuthorship W2185014763A5072760293 @default.
- W2185014763 hasAuthorship W2185014763A5085416114 @default.
- W2185014763 hasBestOaLocation W21850147631 @default.
- W2185014763 hasConcept C126322002 @default.
- W2185014763 hasConcept C134018914 @default.
- W2185014763 hasConcept C176891718 @default.
- W2185014763 hasConcept C185592680 @default.
- W2185014763 hasConcept C2776151105 @default.
- W2185014763 hasConcept C2776175330 @default.
- W2185014763 hasConcept C2776914184 @default.
- W2185014763 hasConcept C2776940978 @default.
- W2185014763 hasConcept C2777391703 @default.
- W2185014763 hasConcept C2777551382 @default.
- W2185014763 hasConcept C2778004101 @default.
- W2185014763 hasConcept C2778772119 @default.
- W2185014763 hasConcept C2778904781 @default.
- W2185014763 hasConcept C2779134260 @default.
- W2185014763 hasConcept C2779306644 @default.
- W2185014763 hasConcept C2779478299 @default.
- W2185014763 hasConcept C2780559512 @default.