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- W2185035960 endingPage "1865" @default.
- W2185035960 startingPage "1857" @default.
- W2185035960 abstract "In Drosophila, most neuronal siblings have different fates ('A/B'). Here we demonstrate that mutations in sanpodo, a tropomodulin actin-binding protein homologue, equalize a diverse array of sibling neuron fates ('B/B'). Loss of Notch signaling gives the same phenotype, whereas loss of numb gives the opposite phenotype ('A/A'). The identical effect of removing either sanpodo or Notch function on the fates of sibling CNS neurons indicates that sanpodo may act in the Notch signaling pathway. In addition, sanpodo and numb show dosage-sensitive interactions and epistasis experiments indicate that sanpodo acts downstream of numb. Taken together, these results show that interactions between sanpodo, the Notch signaling pathway and numb enable CNS sibling neurons to acquire different fates." @default.
- W2185035960 created "2016-06-24" @default.
- W2185035960 creator A5030282445 @default.
- W2185035960 creator A5077877871 @default.
- W2185035960 date "1998-05-15" @default.
- W2185035960 modified "2023-10-14" @default.
- W2185035960 title "Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the <i>Drosophila</i> CNS" @default.
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- W2185035960 doi "https://doi.org/10.1242/dev.125.10.1857" @default.
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