FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2185053404> ?p ?o ?g. }

• W2185053404 endingPage "304" @default.
• W2185053404 startingPage "297" @default.
• W2185053404 abstract "Naturally occurring regulatory T cells (nTregs) play an important role in immunologic tolerance and control immune-mediated pathology in murine models of autoimmune hemolytic anemia. Our aim was to measure nTregs and levels of interleukin (IL) 10 and IL-12 in peripheral blood mononuclear cell (PBMC) cultures from patients with idiopathic warm autoimmune hemolytic anemia (wAIHA) in an attempt to unravel some of the mysteries behind the pathogenesis of this autoimmune disorder.Twenty-seven patients with idiopathic wAIHA and 15 age- and sex-matched controls underwent flow cytometric analysis of CD4+ CD25high FoxP3+ T cells (nTregs) and analysis by enzyme-linked immunosorbent assay of IL-10 and IL-12 in the supernatants of basal and lipopolysaccharide (LPS)-stimulated PBMC cultures.The mean (SD) percentage of circulating CD4+ nTregs in peripheral blood was significantly lower in patients (4.63% [1.0%]) than in controls (9.76% (0.78%])(P<.001). PBMCs from patients had significantly higher basal levels of Il-10 and IL-12, with a dramatic reduction in responsiveness to LPS in vitro compared to controls. There was a significantly negative correlation between the percentage of nTregs and reticulocyte count (RC), basal IL-10, and LPS-stimulated IL-10, and a significantly positive correlation with haptoglobin (Hp) (P<.05). Basal IL-10 and LPS-stimulated IL-10 were positively correlated with RC (P < .001 in both cases) and negatively correlated with Hp (P<.01 and P<.05, respectively).Our study indicates that a reduced percentage of nTregs and IL-10/IL-12 imbalance may play an essential role in the onset and/or maintenance of this AIHA." @default.
• W2185053404 created "2016-06-24" @default.
• W2185053404 creator A5016194329 @default.
• W2185053404 creator A5029178511 @default.
• W2185053404 creator A5032041091 @default.
• W2185053404 date "2011-01-01" @default.
• W2185053404 modified "2023-09-24" @default.
• W2185053404 title "Naturally occurring regulatory T cells and interleukins 10 and 12 in the pathogenesis of idiopathic warm autoimmune hemolytic anemia." @default.
• W2185053404 cites W1560277370 @default.
• W2185053404 cites W1964450510 @default.
• W2185053404 cites W1970672332 @default.
• W2185053404 cites W1972066347 @default.
• W2185053404 cites W1972433111 @default.
• W2185053404 cites W1973002754 @default.
• W2185053404 cites W1977630588 @default.
• W2185053404 cites W1993751578 @default.
• W2185053404 cites W2001070248 @default.
• W2185053404 cites W2006137635 @default.
• W2185053404 cites W2010854505 @default.
• W2185053404 cites W2019060341 @default.
• W2185053404 cites W2024616362 @default.
• W2185053404 cites W2031880380 @default.
• W2185053404 cites W2038689503 @default.
• W2185053404 cites W2042073660 @default.
• W2185053404 cites W2052386553 @default.
• W2185053404 cites W2053226799 @default.
• W2185053404 cites W2055459219 @default.
• W2185053404 cites W2055571197 @default.
• W2185053404 cites W2072718666 @default.
• W2185053404 cites W2092002592 @default.
• W2185053404 cites W2093963507 @default.
• W2185053404 cites W2095069090 @default.
• W2185053404 cites W2095671247 @default.
• W2185053404 cites W2100669936 @default.
• W2185053404 cites W2108291651 @default.
• W2185053404 cites W2122722718 @default.
• W2185053404 cites W2138009200 @default.
• W2185053404 cites W2145453174 @default.
• W2185053404 cites W2148245227 @default.
• W2185053404 cites W2150088486 @default.
• W2185053404 cites W2161545566 @default.
• W2185053404 cites W2164701887 @default.
• W2185053404 cites W2582398023 @default.
• W2185053404 cites W2153204271 @default.
• W2185053404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21721376" @default.
• W2185053404 hasPublicationYear "2011" @default.
• W2185053404 type Work @default.
• W2185053404 sameAs 2185053404 @default.
• W2185053404 citedByCount "4" @default.
• W2185053404 countsByYear W21850534042015 @default.
• W2185053404 countsByYear W21850534042016 @default.
• W2185053404 countsByYear W21850534042023 @default.
• W2185053404 crossrefType "journal-article" @default.
• W2185053404 hasAuthorship W2185053404A5016194329 @default.
• W2185053404 hasAuthorship W2185053404A5029178511 @default.
• W2185053404 hasAuthorship W2185053404A5032041091 @default.
• W2185053404 hasConcept C126322002 @default.
• W2185053404 hasConcept C134018914 @default.
• W2185053404 hasConcept C137061746 @default.
• W2185053404 hasConcept C202751555 @default.
• W2185053404 hasConcept C203014093 @default.
• W2185053404 hasConcept C206396517 @default.
• W2185053404 hasConcept C2776175824 @default.
• W2185053404 hasConcept C2777385706 @default.
• W2185053404 hasConcept C2778024521 @default.
• W2185053404 hasConcept C2778248108 @default.
• W2185053404 hasConcept C2778690821 @default.
• W2185053404 hasConcept C2779306644 @default.
• W2185053404 hasConcept C2779727006 @default.
• W2185053404 hasConcept C2780942790 @default.
• W2185053404 hasConcept C55493867 @default.
• W2185053404 hasConcept C71924100 @default.
• W2185053404 hasConcept C74172505 @default.
• W2185053404 hasConcept C86803240 @default.
• W2185053404 hasConcept C8891405 @default.
• W2185053404 hasConceptScore W2185053404C126322002 @default.
• W2185053404 hasConceptScore W2185053404C134018914 @default.
• W2185053404 hasConceptScore W2185053404C137061746 @default.
• W2185053404 hasConceptScore W2185053404C202751555 @default.
• W2185053404 hasConceptScore W2185053404C203014093 @default.
• W2185053404 hasConceptScore W2185053404C206396517 @default.
• W2185053404 hasConceptScore W2185053404C2776175824 @default.
• W2185053404 hasConceptScore W2185053404C2777385706 @default.
• W2185053404 hasConceptScore W2185053404C2778024521 @default.
• W2185053404 hasConceptScore W2185053404C2778248108 @default.
• W2185053404 hasConceptScore W2185053404C2778690821 @default.
• W2185053404 hasConceptScore W2185053404C2779306644 @default.
• W2185053404 hasConceptScore W2185053404C2779727006 @default.
• W2185053404 hasConceptScore W2185053404C2780942790 @default.
• W2185053404 hasConceptScore W2185053404C55493867 @default.
• W2185053404 hasConceptScore W2185053404C71924100 @default.
• W2185053404 hasConceptScore W2185053404C74172505 @default.
• W2185053404 hasConceptScore W2185053404C86803240 @default.
• W2185053404 hasConceptScore W2185053404C8891405 @default.
• W2185053404 hasIssue "4" @default.
• W2185053404 hasLocation W21850534041 @default.
• W2185053404 hasOpenAccess W2185053404 @default.
• W2185053404 hasPrimaryLocation W21850534041 @default.

• next